Gothe B, Hanekamp L M, Cherniack N S
J Lab Clin Med. 1987 May;109(5):608-16.
To evaluate the reproducibility of respiratory measurements between nights we performed studies in 20 outpatients with stable, moderately severe chronic obstructive pulmonary disease. All patients had symptoms from their lung disease but had no sleep complaints. Their mean age was 61 years, mean 1-second forced expiratory volume was 42% of predicted, and mean functional residual capacity 195% of predicted. Arterial Pco2 averaged 40 +/- 1 (SEM) mm Hg and mean Po2 64 +/- 1 mm Hg. Sleep was monitored for 7 hours by standard techniques on 2 nights 1 week apart. Breathing was assessed by measuring airflow at the nose and mouth with thermistors, and rib cage and abdominal respiratory movements with inductive plethysmography. Oxygen saturation was measured with an ear oximeter. Patients slept on the average 58% of the time in the first night and 63% in the second. Arousals were common but apneas uncommon in both nights. There was no significant difference in median nocturnal O2 saturation on the 2 nights. Tidal volume and minute ventilation, but not respiratory rate, were significantly lower and more variable in rapid eye movement (REM) sleep as compared with wakefulness and non-REM sleep; however, mean values and the variance for tidal volume, respiratory rate, or minute ventilation were similar on both nights.
为评估夜间呼吸测量结果的可重复性，我们对20例病情稳定的中度重度慢性阻塞性肺疾病门诊患者进行了研究。所有患者均有肺部疾病症状，但无睡眠相关主诉。他们的平均年龄为61岁，平均第1秒用力呼气量为预测值的42%，平均功能残气量为预测值的195%。动脉血二氧化碳分压平均为40±1（标准误）mmHg，平均氧分压为64±1 mmHg。采用标准技术，在间隔1周的两个晚上对睡眠进行了7小时的监测。通过热敏电阻测量鼻和口处的气流，并用感应体积描记法测量胸廓和腹部的呼吸运动来评估呼吸情况。用耳式血氧计测量血氧饱和度。患者第一晚平均有58%的时间处于睡眠状态，第二晚为63%。两晚均常见觉醒，但呼吸暂停不常见。两晚夜间血氧饱和度中位数无显著差异。与清醒和非快速眼动睡眠相比，快速眼动睡眠期的潮气量和分钟通气量显著降低且变异性更大，但呼吸频率无显著差异；然而，两晚的潮气量、呼吸频率或分钟通气量的平均值及方差相似。
