Department of Chemistry and Environmental Sciences, UNESP-São Paulo State University, São José do Rio Preto, Brazil.
Curr Gene Ther. 2013 Oct;13(5):358-69. doi: 10.2174/156652321305131212125042.
The delivery of small interfering RNAs (siRNAs) is a promising approach to silencing gene expression aimed at treating infections, cancer, neurodegenerative diseases and various other disorders. Recent progress in this area has been achieved with nanodevices possessing multiple properties and assembled with new, biodegradable, synthetic polymers and polysaccharides. Different synthetic routes and multiple strategies, such as multilayer systems and stimuliresponsive polymers, have been developed to attain high efficiencies. This review covers the most important, promising and successful approaches to improve siRNA delivery. It is a concise report on multiple strategies employed, including cell-specific delivery coupling ligands or antibodies with nanodevices to improve siRNA efficiency and specificity.
小干扰 RNA（siRNA）的递呈是一种有前途的基因沉默方法，旨在治疗感染、癌症、神经退行性疾病和各种其他疾病。在这一领域的最新进展是使用具有多种特性的纳米器件来实现的，这些纳米器件与新型可生物降解的合成聚合物和多糖组装在一起。不同的合成途径和多种策略，如多层系统和刺激响应性聚合物，已经被开发出来以获得高效率。本综述涵盖了提高 siRNA 递呈效率的最重要、最有前途和最成功的方法。这是一篇关于多种策略的简明报告，包括将配体或抗体与纳米器件结合进行细胞特异性递呈，以提高 siRNA 的效率和特异性。
