Division of Pulmonary, Allergy, & Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pa.
J Allergy Clin Immunol. 2014 Jan;133(1):49-56. doi: 10.1016/j.jaci.2013.11.005.
In 2013, several themes emerged: (1) a dedicated search for new therapies using new mechanisms; (2) the importance of the plasticity of the immune system (eg, that molecules that mediate inflammation in one setting can promote its resolution and return to homeostasis in other circumstances); (3) the complex role of viruses in asthma exacerbations; (4) the similarities and differences among asthma, asthma in smokers, and chronic obstructive pulmonary disease; and (5) the importance of understanding asthma phenotypes and their stability over time. Once new therapeutics pass the initial clinical trials, patient-oriented and real-world research will be needed.
2013 年，出现了几个主题：（1）专注于使用新机制寻找新疗法；（2）免疫系统可塑性的重要性（例如，在一种情况下介导炎症的分子可以促进其解决并在其他情况下恢复到体内平衡）；（3）病毒在哮喘恶化中的复杂作用；（4）哮喘、吸烟者哮喘和慢性阻塞性肺疾病之间的相似性和差异；（5）了解哮喘表型及其随时间的稳定性的重要性。一旦新的疗法通过初步临床试验，就需要进行以患者为导向和真实世界的研究。
