患有严重哮喘的儿童具有独特的与氧化应激相关的代谢组学特征。
Children with severe asthma have unique oxidative stress-associated metabolomic profiles.
机构信息
Department of Pediatrics, Emory University School of Medicine, Atlanta, Ga; Children's Healthcare of Atlanta Center for Developmental Lung Biology, Atlanta, Ga.
Department of Medicine, Emory University School of Medicine, Atlanta, Ga; College of Pharmacy, Korea University, Seong, Korea.
出版信息
J Allergy Clin Immunol. 2014 Jan;133(1):258-61.e1-8. doi: 10.1016/j.jaci.2013.10.012.
Abstract
Children with severe asthma have unique metabolic derangements associated with oxidative stress-related pathways. These metabolic differences may contribute to corticosteroid insensitivity in severe asthma and may be novel targets for further study and therapeutic intervention.
摘要
患有严重哮喘的儿童存在与氧化应激相关途径相关的独特代谢紊乱。这些代谢差异可能导致严重哮喘中的皮质类固醇不敏感性，并可能成为进一步研究和治疗干预的新靶点。
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