Ferraro Valentina Agnese, Zanconato Stefania, Carraro Silvia
Unit of Pediatric Allergy and Respiratory Medicine, Women's and Children's Health Department, University of Padova, 35122 Padova, Italy.
Children (Basel). 2023 Aug 25;10(9):1452. doi: 10.3390/children10091452.
: Asthma is the most common chronic condition in children. It is a complex non-communicable disease resulting from the interaction of genetic and environmental factors and characterized by heterogeneous underlying molecular mechanisms. Metabolomics, as with the other omic sciences, thanks to the joint use of high-throughput technologies and sophisticated multivariate statistical methods, provides an unbiased approach to study the biochemical-metabolic processes underlying asthma. The of this narrative review is the analysis of the metabolomic studies in pediatric asthma published in the past 10 years, focusing on the prediction of asthma development, endotype characterization and pharmaco-metabolomics. : A total of 43 relevant published studies were identified searching the MEDLINE/Pubmed database, using the following terms: "asthma" AND "metabolomics". The following filters were applied: language (English), age of study subjects (0-18 years), and publication date (last 10 years). : Several studies were identified within the three areas of interest described in the aim, and some of them likely have the potential to influence our clinical approach in the future. Nonetheless, further studies are needed to validate the findings and to assess the role of the proposed biomarkers as possible diagnostic or prognostic tools to be used in clinical practice.
哮喘是儿童中最常见的慢性疾病。它是一种复杂的非传染性疾病，由遗传和环境因素相互作用导致，具有异质性的潜在分子机制。代谢组学与其他组学科学一样，由于高通量技术和复杂的多变量统计方法的联合使用，为研究哮喘潜在的生化代谢过程提供了一种无偏倚的方法。本叙述性综述的目的是分析过去10年发表的关于儿童哮喘的代谢组学研究，重点关注哮喘发展的预测、内型特征分析和药物代谢组学。通过在MEDLINE/Pubmed数据库中检索，使用以下检索词：“哮喘”和“代谢组学”，共识别出43项相关已发表研究。应用了以下筛选条件：语言（英语）、研究对象年龄（0至18岁）和发表日期（过去10年）。在目标中描述的三个感兴趣领域内识别出了多项研究，其中一些研究可能在未来有影响我们临床方法的潜力。尽管如此，仍需要进一步研究来验证这些发现，并评估所提出的生物标志物作为可能用于临床实践的诊断或预后工具的作用。
