Ghosh K, Mohanty D, Rana K S, Hassan S W, Garewal G, Das K C
Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(6):766-75.
Plasma UBBC-B12 and transcobalamins were measured in 112 patients suffering from different haematological disorders. The data showed different patterns of changes in plasma transcobalamin profile in different haematological disorders. Plasma UBBC-B12 and transcobalamins were significantly higher than normal in untreated chronic myeloid leukaemia, acute promyelocytic leukaemia, nutritional megaloblastic anaemia and in refractory anaemias with hypercellular marrow. Normal levels of these proteins were noted in chronic lymphatic leukaemias, in primary and secondary hypereosinophilic states and in multiple myeloma. Subnormal levels of these proteins were observed in hypoplastic anaemia and acute lymphoblastic leukaemia. Chronic myeloid leukaemia patients during blast crisis and acute myeloid leukaemia patients except those suffering from acute promyelocytic leukaemia showed varying pattern of plasma transcobalamins depending on type of blast crisis or FAB subtype of AML. The significance of these changes in plasma transcobalamins have been discussed along with the experience of other workers in this field.
对112例患有不同血液系统疾病的患者测定了血浆未结合维生素B12（UBBC-B12）和转钴胺素。数据显示，在不同血液系统疾病中，血浆转钴胺素谱呈现出不同的变化模式。在未经治疗的慢性粒细胞白血病、急性早幼粒细胞白血病、营养性巨幼细胞贫血以及骨髓细胞增多的难治性贫血中，血浆UBBC-B12和转钴胺素显著高于正常水平。在慢性淋巴细胞白血病、原发性和继发性嗜酸性粒细胞增多症以及多发性骨髓瘤中，这些蛋白质水平正常。在再生障碍性贫血和急性淋巴细胞白血病中观察到这些蛋白质水平低于正常。慢性粒细胞白血病患者在急变期以及急性髓细胞白血病患者（除急性早幼粒细胞白血病患者外），其血浆转钴胺素模式因急变类型或急性髓细胞白血病的FAB亚型而异。本文结合该领域其他研究者的经验，对血浆转钴胺素这些变化的意义进行了讨论。
