Anger G, Senf L, Schmidt U, Mattheus A
Z Gesamte Inn Med. 1979 Aug 1;34(15):suppl 196-7.
By means of a test set of the Isocommerz (GDR) determinations of vitamin B12 in the serum were carried out according to the principle of the competitive protein binding. The normal values lie between 200 and 1,000 pg/ml serum. Clearly decreased levels of vitamin B12 are found in the pernicious anaemia, in other megaloblastic anaemias and in disturbances of the resorption after resection of the stomach. Increased values can be stated in the untreated chronic myelosis and in the blast episode. Under Busulphan-therapy a significant decrease of the values of vitamin B12 develops. The method seems to be practically important for the well-timed recognition of deficiency conditions of vitamin B12 in beginning pernicious anaemia, in disturbances of intestinal resorption after resection of the stomach and for the observation of the course of the chronic myelosis.
借助于东德伊索科默兹公司的检测设备，按照竞争性蛋白结合原理对血清中的维生素B12进行测定。正常数值范围为每毫升血清200至1000皮克。在恶性贫血、其他巨幼细胞贫血以及胃切除术后吸收障碍的情况下，可发现维生素B12水平明显降低。在未经治疗的慢性粒细胞白血病及原始细胞危象中，数值会升高。在白消安治疗期间，维生素B12数值会显著下降。该方法对于早期识别恶性贫血初期维生素B12缺乏状况、胃切除术后肠道吸收障碍以及观察慢性粒细胞白血病病程似乎具有重要实际意义。
