[甲苯二异氰酸酯对工人肺功能的影响]

[Effect of toluene diisocyanate on lung function of workers].

作者信息

Liu Bao-feng, Liu Hui, Zhang Ming, Zhao Xin, Yang De-yi, Ren Jie, Wang Yan-rang

机构信息

Institute of Occupational Disease Control and Prevention, Tianjin Centers for Disease Control and Prevention Tianjin 300011, China.

Institute of Occupational Disease Control and Prevention, Tianjin Centers for Disease Control and Prevention Tianjin 300011, China. E-mail:

出版信息

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013 Nov;31(11):844-5.

PMID:24370296

Abstract

OBJECTIVE

To investigate the effect of long-term exposure to toluene diisocyanate (TDI) on the lung function of TDI-exposed workers.

METHODS

A factory was selected for this occupational epidemiological investigation. The workers who were exposed to TDI and had complete physical examination records in recent 3 years were the exposed group (n = 45), while the company's administrative staff, logistics staff, and other non-TDI-exposed workers who had complete physical examination records in recent 3 years were the control group (n = 47). The two groups were compared in terms of lung function indices.

RESULTS

Compared with the control group, the 2009 exposure group had significantly lower forced expiratory volume in one second (FEV1.0), FEV1.0/forced vital capacity (FVC), and maximal expiratory flow at 25% of FVC (MEF25) (P < 0.05), the 2010 exposure group had significantly lower FEV1.0, FEV1.0/FVC,maximum voluntary ventilation (MVV), and maximal expiratory flow at 50% of FVC (MEF50) (P < 0.05), and the 2011 exposure group had significantly lower FEV1.0, FEV1.0/FVC, peak expiratory flow (PEF), MEF25, and MEF50 (P < 0.05).

CONCLUSION

Long-term exposure to TDI can lead to certain impairment of lung function in workers, which may be reflected by decreased lung function indices such as vital capacity, FVC, FEV1.0, FEV1.0/FVC, PEF, and MVV.

摘要

目的

探讨长期接触甲苯二异氰酸酯（TDI）对TDI接触工人肺功能的影响。

方法

选择一家工厂进行本次职业流行病学调查。将接触TDI且近3年有完整体检记录的工人作为暴露组（n = 45），将公司行政人员、后勤人员及其他近3年有完整体检记录的非TDI接触工人作为对照组（n = 47）。比较两组的肺功能指标。

结果

与对照组相比，2009年暴露组的一秒用力呼气容积（FEV1.0）、FEV1.0/用力肺活量（FVC）及FVC 25%时的最大呼气流量（MEF25）显著降低（P < 0.05）；2010年暴露组的FEV1.0、FEV1.0/FVC、最大自主通气量（MVV）及FVC 50%时的最大呼气流量（MEF50）显著降低（P < 0.05）；2011年暴露组的FEV1.0、FEV1.0/FVC、呼气峰值流速（PEF）、MEF25及MEF50显著降低（P < 0.05）。