State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Int J Biol Macromol. 2014 Mar;64:395-401. doi: 10.1016/j.ijbiomac.2013.12.029. Epub 2013 Dec 24.
In this study, the chemoprotective effects of Ganoderma atrum polysaccharide (PSG-1) in cyclophosphamide (Cy) treated mice were investigated. In Cy-treated mice, PSG-1 treatment accelerated recovery dose-dependently of peripheral red blood cells, white blood cells and platelets, enhanced splenic natural killer cell activity and cytotoxic T lymphocyte activity. In addition, PSG-1 elevated CD4(+) T lymphocyte counts as well as the CD4(+)/CD8(+) ratio dose-dependently. Furthermore, PSG-1 restored the levels of IL-2, INF-γ, IL-10, IgA, IgM and IgG, as well as hemolysin in the sera. Finally, PSG-1 can also significantly increase the total antioxidant capacity, activities of superoxidase dismutase, catalase and glutathione peroxidase, and decrease the malondialdehyde level in vivo. These findings indicate that PSG-1 plays an important role in the protection against myelosuppression and immunosuppression and oxidative stress in Cy-treated mice and could be a potential immunomodulatory agent.
在这项研究中，研究了灵芝多糖（PSG-1）在环磷酰胺（Cy）处理的小鼠中的化学保护作用。在 Cy 处理的小鼠中，PSG-1 处理剂量依赖性地加速外周血红细胞、白细胞和血小板的恢复，增强了脾自然杀伤细胞活性和细胞毒性 T 淋巴细胞活性。此外，PSG-1 剂量依赖性地升高 CD4+T 淋巴细胞计数和 CD4+/CD8+比值。此外，PSG-1 还可以恢复血清中的 IL-2、INF-γ、IL-10、IgA、IgM 和 IgG 水平以及溶血素。最后，PSG-1 还可以显著增加体内总抗氧化能力、超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性，并降低丙二醛水平。这些发现表明 PSG-1 在保护 Cy 处理的小鼠的骨髓抑制、免疫抑制和氧化应激方面发挥重要作用，并且可能是一种潜在的免疫调节剂。
