肾脏相关放射学：常染色体显性遗传性多囊肾病的放射影像学表现。
Renal relevant radiology: radiologic imaging in autosomal dominant polycystic kidney disease.
机构信息
Departments of Medicine and, †Radiology, Emory University School of Medicine, Atlanta, Georgia.
出版信息
Clin J Am Soc Nephrol. 2014 Feb;9(2):406-15. doi: 10.2215/CJN.08940813. Epub 2013 Dec 26.
Abstract
Autosomal-dominant polycystic kidney disease is a systemic disorder and the most common hereditary renal disease, which is characterized by cyst growth, progressive renal enlargement, and development of renal failure. The cystic nature of autosomal dominant polycystic kidney disease and its renal and extrarenal complications (kidney stones, cyst hemorrhage, intracerebral aneurysm, liver cysts, cardiac valve abnormalities, etc.) give radiologic imaging studies a central role in the management of these patients. This article reviews the indications, comparative use, and limitation of various imaging modalities (ultrasonography, magnetic resonance imaging, computerized tomography scan, Positron emission tomography scan, and renal scintigraphy) for the diagnosis and management of complications in autosomal dominant polycystic kidney disease. Finally, this work provides evidence for the value of total kidney volume to predict disease progression in autosomal dominant polycystic kidney disease.
摘要
常染色体显性多囊肾病是一种全身性疾病，也是最常见的遗传性肾病，其特征为囊肿生长、进行性肾增大和肾衰竭发展。常染色体显性多囊肾病的囊性本质及其肾脏和肾外并发症（肾结石、囊肿出血、颅内动脉瘤、肝囊肿、心脏瓣膜异常等）使放射影像学研究在这些患者的管理中发挥核心作用。本文回顾了各种成像方式（超声、磁共振成像、计算机断层扫描、正电子发射断层扫描和肾闪烁显像）在常染色体显性多囊肾病的诊断和并发症管理中的适应证、比较应用和局限性。最后，本工作为用肾脏总体积预测常染色体显性多囊肾病的疾病进展提供了依据。
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