Druetz Thomas, Siekmans Kendra, Goossens Sylvie, Ridde Valéry, Haddad Slim
Research Centre of the University of Montreal Hospital Centre (CRCHUM), 850 Rue Saint-Denis, Montreal, QC H2X 0A9, Canada School of Public Health, University of Montreal, 7101 Avenue du Parc, Montreal, QC H3N 1X9, Canada Healthbridge, 1 Nicholas Street, Ottawa, ON K1N 7B7, Canada and Independent Consultant, Paris, France Research Centre of the University of Montreal Hospital Centre (CRCHUM), 850 Rue Saint-Denis, Montreal, QC H2X 0A9, Canada School of Public Health, University of Montreal, 7101 Avenue du Parc, Montreal, QC H3N 1X9, Canada Healthbridge, 1 Nicholas Street, Ottawa, ON K1N 7B7, Canada and Independent Consultant, Paris, France
Research Centre of the University of Montreal Hospital Centre (CRCHUM), 850 Rue Saint-Denis, Montreal, QC H2X 0A9, Canada School of Public Health, University of Montreal, 7101 Avenue du Parc, Montreal, QC H3N 1X9, Canada Healthbridge, 1 Nicholas Street, Ottawa, ON K1N 7B7, Canada and Independent Consultant, Paris, France.
Health Policy Plan. 2015 Mar;30(2):253-66. doi: 10.1093/heapol/czt104. Epub 2013 Dec 25.
Pneumonia causes around 750 000 child deaths per year in sub-Saharan African (SSA) countries. The lack of accessibility to prompt and effective treatment is an important contributor to this burden. Community case management of pneumonia (CCMp) uses trained community health workers (CHWs) to administer antibiotics to suspected child pneumonia cases in villages. This strategy has been gaining momentum in low- and middle-income countries, and the World Health Organization and United Nations children's fund have recently encouraged countries to broaden community case management to other diseases. Recommendations in favour CCMp are based on three meta-analyses showing its efficacy to reduce childhood mortality and morbidity attributable to pneumonia although most of the studies in the meta-analyses were conducted in Asian countries. This is problematic as community case management strategies have been implemented in very different ways in Asian and SSA countries, partly due to differences in malaria prevalence. Therefore, we conducted a narrative synthesis to systematically review the evidence on CCMp in SSA. Results show that there is a lack of evidence concerning its efficacy and effectiveness in SSA, irrespective of whether case management is integrated with other diseases or not. CHWs encounter difficulties in counting the respiratory rate. Their adherence to the guidelines is poorer when they are required to manage several illnesses or children with severe signs. CCMp thus encompasses issues of over-treatment and missed treatment, with potentially negative consequences such as increased lethality in severe cases and antibiotics resistance. The current lack of evidence concerning its efficacy, effectiveness and the factors leading to successful implementation, coupled with CHWs' poor adherence, demand a thorough examination of the legitimacy of implementing CCMp in SSA countries.
在撒哈拉以南非洲(SSA)国家,肺炎每年导致约75万儿童死亡。缺乏及时有效的治疗是造成这一负担的重要原因。社区肺炎病例管理(CCMp)利用经过培训的社区卫生工作者(CHW)为村庄中疑似儿童肺炎病例施用抗生素。这一策略在低收入和中等收入国家正逐渐兴起,世界卫生组织和联合国儿童基金会最近鼓励各国将社区病例管理扩展到其他疾病。支持CCMp的建议基于三项荟萃分析,这些分析表明其在降低肺炎所致儿童死亡率和发病率方面的有效性,尽管荟萃分析中的大多数研究是在亚洲国家进行的。这存在问题,因为社区病例管理策略在亚洲和SSA国家的实施方式截然不同,部分原因是疟疾流行率存在差异。因此,我们进行了一项叙述性综述,以系统地回顾SSA地区CCMp的证据。结果表明,无论病例管理是否与其他疾病相结合,在SSA地区都缺乏关于其有效性和效果的证据。CHW在计算呼吸频率时遇到困难。当他们需要管理多种疾病或有严重症状的儿童时,他们对指南的遵守情况较差。因此,CCMp存在过度治疗和漏诊问题,可能会产生负面后果,如严重病例中死亡率增加和抗生素耐药性。目前缺乏关于其有效性、效果以及导致成功实施因素的证据,再加上CHW的依从性较差,这就需要对在SSA国家实施CCMp的合理性进行彻底审查。