DABO硼酸酯：用于铃木-宫浦交叉偶联反应的稳定杂环硼酸配合物
DABO Boronates: Stable Heterocyclic Boronic Acid Complexes for Use in Suzuki-Miyaura Cross-Coupling Reactions.
作者信息
Reilly Maureen K, Rychnovsky Scott D
机构信息
1102 NSII, Department of Chemistry, University of California, Irvine. Irvine, CA 92697-2025.
出版信息
Synlett. 2011 Oct 1;2011(16). doi: 10.1055/s-0030-1261218.
Abstract
Diethanolamine complexed heterocyclic boronic acids (DABO boronates) are air-stable reagents that can be used directly in Suzuki-Miyaura reactions in the presence of water or a protic co-solvent. Interestingly, heterocyclic DABO boronates can be stored for extended periods of time at room temperature with no noticeable degradation, unlike their boronic acid counterparts. Heterocyclic DABO boronates constitute an operationally simple and efficient alternative to other boronic acid derivatives as coupling partners in palladium catalyzed cross-coupling reactions under standard Suzuki-Miyaura conditions.
摘要
二乙醇胺络合的杂环硼酸酯（DABO硼酸酯）是空气稳定的试剂，可在水或质子性共溶剂存在下直接用于铃木-宫浦反应。有趣的是，与硼酸类似物不同，杂环DABO硼酸酯可以在室温下长时间储存而无明显降解。在标准铃木-宫浦条件下，杂环DABO硼酸酯作为钯催化交叉偶联反应中的偶联伙伴，是其他硼酸衍生物在操作上简单且高效的替代品。
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