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非剥脱性二氧化碳点阵激光光动力疗法治疗光化性角化病

Photodynamic therapy with ablative carbon dioxide fractional laser in treatment of actinic keratosis.

作者信息

Jang Yong Hyun, Lee Dong Jun, Shin Jaeyoung, Kang Hee Young, Lee Eun-So, Kim You Chan

机构信息

Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea.

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

出版信息

Ann Dermatol. 2013 Nov;25(4):417-22. doi: 10.5021/ad.2013.25.4.417. Epub 2013 Nov 30.

DOI:10.5021/ad.2013.25.4.417
PMID:24371387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3870208/
Abstract

BACKGROUND

Recently, photodynamic therapy (PDT) has been shown to be an effective first-line treatment for actinic keratosis (AK). However, a major limitation of PDT is the long incubation time required to allow penetration of the photosensitizer.

OBJECTIVE

The aim of this study was to assess if pretreatment with an ablative carbon dioxide (CO2) fractional laser can reduce the incubation time of the photosensitizer.

METHODS

Initially, 29 patients with a total of 34 AK lesions were treated with an ablative CO2 fractional laser at Ajou University Hospital between January and December 2010. Immediately after the laser treatment, topical 20% 5-aminolevulinic acid or methyl-aminolevulinate was applied to the AK lesions and incubated for 70 to 90 minutes. Then, the treated areas were illuminated with a red light source. Improvement was clinically or histologically assessed eight weeks after the treatment.

RESULTS

In spite of the short incubation time, 24 lesions (70.6%) showed a complete response (CR) within three sessions of PDT (10 lesions a clinical CR and 14 lesions a clinical/histological CR). There were no significant side effects associated with the combination of ablative CO2 fractional laser and PDT.

CONCLUSION

Ablative CO2 fractional laser may be considered an additional treatment option for reducing the incubation time of the photosensitizer in PDT.

摘要

背景

最近，光动力疗法（PDT）已被证明是治疗光化性角化病（AK）的一种有效的一线治疗方法。然而，PDT的一个主要局限性是需要较长的孵育时间以使光敏剂渗透。

目的

本研究的目的是评估用剥脱性二氧化碳（CO2）分次激光预处理是否可以缩短光敏剂的孵育时间。

方法

最初，2010年1月至12月期间，在韩国亚洲大学医院对29例患者共34个AK皮损进行了剥脱性CO2分次激光治疗。激光治疗后立即在AK皮损上外用20%的5-氨基酮戊酸或甲基氨基酮戊酸，并孵育70至90分钟。然后，用红色光源照射治疗区域。治疗8周后进行临床或组织学评估改善情况。

结果

尽管孵育时间短，但24个皮损（70.6%）在3次PDT治疗后显示完全缓解（CR）（10个皮损为临床CR，14个皮损为临床/组织学CR）。剥脱性CO2分次激光与PDT联合使用未出现明显副作用。

结论

剥脱性CO2分次激光可被视为一种额外的治疗选择，用于缩短PDT中光敏剂的孵育时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1785/3870208/cbb4fad4932f/ad-25-417-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1785/3870208/ec9a5a5fbd63/ad-25-417-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1785/3870208/b4486fce5791/ad-25-417-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1785/3870208/e699cf516b0a/ad-25-417-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1785/3870208/cbb4fad4932f/ad-25-417-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1785/3870208/ec9a5a5fbd63/ad-25-417-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1785/3870208/b4486fce5791/ad-25-417-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1785/3870208/e699cf516b0a/ad-25-417-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1785/3870208/cbb4fad4932f/ad-25-417-g004.jpg

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