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聚乙二醇化干扰素α-2a和利巴韦林治疗慢性丙型肝炎时诱发广泛银屑病

Extensive psoriasis induced by pegylated interferon alfa-2a and ribavirin in the treatment of chronic hepatitis C.

作者信息

Kim Gun-Wook, Jwa Seung-Wook, Song Margaret, Kim Hoon-Soo, Kim Byung-Soo, Kim Moon-Bum, Ko Hyun-Chang

机构信息

Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.

Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Bio-medical Research Institute, Pusan National University Hospital, Busan, Korea.

出版信息

Ann Dermatol. 2013 Nov;25(4):479-82. doi: 10.5021/ad.2013.25.4.479. Epub 2013 Nov 30.

DOI:10.5021/ad.2013.25.4.479
PMID:24371397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3870218/
Abstract

A 56-year-old man with chronic hepatitis C was treated with pegylated interferon alfa-2a in combination with ribavirin. However, psoriatic lesions appeared and worsened dramatically during therapy. Because of the extensive skin eruptions, he stopped therapy for chronic hepatitis C and subsequently started narrow-band ultraviolet B phototherapy and topical calcipotriol/betamethasone dipropionate ointment. After this, the psoriasis improved in a slow but comprehensive manner. Our case suggests that physicians should keep in mind the possibility of psoriasis as a side effect of interferon treatment for chronic hepatitis C.

摘要

一名56岁的慢性丙型肝炎男性患者接受了聚乙二醇化干扰素α-2a联合利巴韦林治疗。然而，银屑病皮损在治疗期间出现并急剧恶化。由于广泛的皮肤疹，他停止了慢性丙型肝炎的治疗，随后开始窄谱紫外线B光疗和外用卡泊三醇/倍他米松二丙酸酯软膏。此后，银屑病以缓慢但全面的方式得到改善。我们的病例提示，医生应牢记银屑病作为慢性丙型肝炎干扰素治疗副作用的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/598b/3870218/6b1199f9a1fc/ad-25-479-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/598b/3870218/bf2159000552/ad-25-479-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/598b/3870218/6b1199f9a1fc/ad-25-479-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/598b/3870218/bf2159000552/ad-25-479-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/598b/3870218/6b1199f9a1fc/ad-25-479-g002.jpg

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