Division of Dermatology, Department of Medicine, University of California, San Diego, USA.
J Eur Acad Dermatol Venereol. 2013 Jun;27(6):771-8. doi: 10.1111/j.1468-3083.2012.04582.x. Epub 2012 Jun 1.
Interferon-alpha (IFN-α) therapy is used to treat hepatitis C infection. The exacerbation and occurrence of psoriasis in hepatitis C patients treated with IFN-α is increasingly recognized, but the distinct associated features, aetiology and management have not been reviewed.
To review all published cases of hepatitis C patients who developed psoriasis while receiving IFN-α therapy.
The review was conducted by searching the PubMed database using the keywords 'hepatitis C' AND 'psoriasis.' In addition, references to additional publications not indexed for PubMed were followed to obtain a complete record of published data.
We identified 32 publications describing 36 subjects who developed a psoriatic eruption while receiving IFN-α therapy for hepatitis C. Topical therapies were a commonly employed treatment modality, but led to resolution in only 30% of cases in which they were employed solely. Cessation of IFN-α therapy led to resolution in 93% of cases. Hundred per cent of those who developed psoriasis while on IFN-α therapy responded to systemic therapy and were able to continue the drug.
Further studies and analysis of IFN-α-induced lesions are necessary to clarify the role of IFN-α and the hepatitis C virus in the development of psoriatic lesions.
干扰素-α（IFN-α）疗法用于治疗丙型肝炎感染。越来越多的人认识到，丙型肝炎患者在接受 IFN-α 治疗时会加剧或出现银屑病，但尚未对其明确的相关特征、病因和治疗进行综述。
回顾所有接受 IFN-α 治疗的丙型肝炎患者出现银屑病的病例。
通过在 PubMed 数据库中使用关键词“丙型肝炎”和“银屑病”进行检索，进行了本次综述。此外，还查阅了未被 PubMed 索引的其他出版物的参考文献，以获得已发表数据的完整记录。
我们共找到 32 篇描述 36 例患者在接受 IFN-α 治疗丙型肝炎时出现银屑病发作的文献。局部治疗是一种常用的治疗方法，但单独使用时仅能使 30%的病例得到缓解。停止 IFN-α 治疗后，93%的病例得到缓解。100%的在 IFN-α 治疗期间发生银屑病的患者对系统治疗有反应，并能够继续使用该药物。
有必要进一步研究和分析 IFN-α 诱导的病变，以阐明 IFN-α 和丙型肝炎病毒在银屑病病变发展中的作用。
