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达托霉素治疗天然三尖瓣和二尖瓣耐甲氧西林金黄色葡萄球菌心内膜炎合并肺脓毒性栓子失败

Daptomycin Failure for Treatment of Pulmonary Septic Emboli in Native Tricuspid and Mitral Valve Methicillin-Resistant Staphylococcus aureus Endocarditis.

作者信息

Zainah Hadeel, Zervos Marcus, Stephane Wassim, Chamas Alhelo Sara, Alkhoury Ghattas, Weinmann Allison

机构信息

Infectious Diseases Department, Henry Ford Hospital, 2799 W. Grand Boulevard, CFP-304, Detroit, MI 48202, USA.

出版信息

Case Rep Infect Dis. 2013;2013:653582. doi: 10.1155/2013/653582. Epub 2013 Nov 25.

DOI:10.1155/2013/653582
PMID:24371532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3859033/
Abstract

Daptomycin has been used with success for the treatment of right-sided methicillin-resistant Staphylococcus aureus (MRSA) endocarditis. However, its efficacy has not been completely assessed for the treatment of MRSA endocarditis when it is associated with pulmonary septic emboli. Hereby, we present a case of MRSA mitral and tricuspid native valve endocarditis with pulmonary septic emboli, which was treated with daptomycin as a sole agent, resulting in worsening pulmonary infiltrates and treatment failure.

摘要

达托霉素已成功用于治疗右侧耐甲氧西林金黄色葡萄球菌（MRSA）心内膜炎。然而，当它与肺脓毒性栓子相关时，其治疗MRSA心内膜炎的疗效尚未得到全面评估。在此，我们报告一例伴有肺脓毒性栓子的MRSA二尖瓣和三尖瓣原发性瓣膜心内膜炎病例，该病例仅用达托霉素治疗，导致肺部浸润加重和治疗失败。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/c9dc4cb74b70/CRIM.ID2013-653582.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/67fc15d84adc/CRIM.ID2013-653582.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/a9480f2f0fcd/CRIM.ID2013-653582.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/aff25e1d0641/CRIM.ID2013-653582.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/80f8295d25e0/CRIM.ID2013-653582.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/c9dc4cb74b70/CRIM.ID2013-653582.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/67fc15d84adc/CRIM.ID2013-653582.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/a9480f2f0fcd/CRIM.ID2013-653582.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/aff25e1d0641/CRIM.ID2013-653582.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/80f8295d25e0/CRIM.ID2013-653582.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/3859033/c9dc4cb74b70/CRIM.ID2013-653582.005.jpg

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本文引用的文献

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Ceftaroline for meticillin-resistant Staphylococcus aureus bacteraemia: case series and review of the literature.头孢洛林治疗耐甲氧西林金黄色葡萄球菌菌血症：病例系列和文献复习。
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High dose of trimethoprim-sulfamethoxazole and daptomycin as a therapeutic option for MRSA endocarditis with large vegetation complicated by embolic stroke: a case report and literature review.大剂量甲氧苄啶-磺胺甲恶唑和达托霉素作为治疗伴有大赘生物并并发栓塞性中风的耐甲氧西林金黄色葡萄球菌心内膜炎的一种治疗选择：病例报告及文献综述
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Pharmacotherapy for methicillin-resistant Staphylococcus aureus nosocomial pneumonia.
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J Antimicrob Chemother. 2011 Apr;66 Suppl 3:iii33-44. doi: 10.1093/jac/dkr097.
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Clinical, molecular and epidemiological description of a cluster of community-associated methicillin-resistant Staphylococcus aureus isolates from injecting drug users with bacteraemia.注射吸毒者血流感染的社区相关性耐甲氧西林金黄色葡萄球菌感染聚集的临床、分子和流行病学描述。
Clin Microbiol Infect. 2010 Jul;16(7):921-6. doi: 10.1111/j.1469-0691.2009.02969.x. Epub 2009 Nov 11.
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Septic pulmonary emboli and bacteremia associated with deep tissue infections caused by community-acquired methicillin-resistant Staphylococcus aureus.与社区获得性耐甲氧西林金黄色葡萄球菌引起的深部组织感染相关的脓毒性肺栓塞和菌血症。
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Pharmacologic treatment options for nosocomial pneumonia involving methicillin-resistant Staphylococcus aureus.耐甲氧西林金黄色葡萄球菌所致医院获得性肺炎的药物治疗选择
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N Engl J Med. 2006 Aug 17;355(7):653-65. doi: 10.1056/NEJMoa053783.