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Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial.阿法替尼对比安慰剂用于厄洛替尼、吉非替尼治疗失败或两者都失败，以及一线或二线化疗后进展、转移性非小细胞肺癌患者（LUX-Lung 1）：一项 2b/3 期随机试验。
Lancet Oncol. 2012 May;13(5):528-38. doi: 10.1016/S1470-2045(12)70087-6. Epub 2012 Mar 26.
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Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: a Gynecologic Oncology Group study.曲妥珠单抗治疗晚期或复发性HER2阳性子宫内膜癌女性的II期试验：一项妇科肿瘤学组研究
Gynecol Oncol. 2010 Jan;116(1):15-20. doi: 10.1016/j.ygyno.2009.09.025. Epub 2009 Oct 18.
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Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu.曲妥珠单抗治疗HER2/neu过表达的晚期或复发性子宫内膜癌患者。
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An exploratory analysis of HER-2 amplification and overexpression in advanced endometrial carcinoma: a Gynecologic Oncology Group study.晚期子宫内膜癌中HER-2扩增与过表达的探索性分析：一项妇科肿瘤学组研究
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HER-2/neu overexpression in uterine papillary serous cancers and its possible therapeutic implications.HER-2/neu在子宫浆液性乳头状癌中的过表达及其可能的治疗意义。
Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1897-902. doi: 10.1111/j.1525-1438.2006.00664.x.
6
Amplification of c-erbB2 oncogene: a major prognostic indicator in uterine serous papillary carcinoma.c-erbB2癌基因扩增：子宫浆液性乳头状癌的一项主要预后指标。
Cancer. 2005 Oct 1;104(7):1391-7. doi: 10.1002/cncr.21308.
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Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.子宫浆液性乳头状癌中Her-2/neu的过表达与扩增
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子宫浆液性乳头状癌中的人表皮生长因子受体2靶向治疗

Her-2 targeting in uterine papillary serous carcinoma.

作者信息

Talwar Sumit, Cohen Seth

机构信息

Department of Hematology/Oncology, St. Luke's Roosevelt Hospital Center, New York, NY, USA.

出版信息

Gynecol Oncol Case Rep. 2012 May 8;2(3):94-6. doi: 10.1016/j.gynor.2012.05.003. eCollection 2012.

DOI:10.1016/j.gynor.2012.05.003
PMID:24371631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3860722/
Abstract

► A case of metastatic uterine papillary serous cancer with Her-2 gene amplification. ► Was treated with a Her-2 targeted agent and achieved durable remission. ► Her-2 targeting should be considered alone or in combination with chemotherapy.

摘要

► 1例伴有Her-2基因扩增的转移性子宫浆液性癌。

► 接受了Her-2靶向药物治疗并实现了持久缓解。

► 应单独或联合化疗考虑Her-2靶向治疗。