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一名接受贝伐单抗治疗的复发性卵巢癌患者发生椎动脉夹层和脑梗死。

Vertebral artery dissection and cerebral infarction in a patient with recurrent ovarian cancer receiving bevacizumab.

作者信息

Mantia-Smaldone Gina M, Bagley Linda J, Kasner Scott E, Chu Christina S

机构信息

Division of Gynecologic Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Gynecol Oncol Case Rep. 2013 Apr 11;5:37-9. doi: 10.1016/j.gynor.2013.04.002. eCollection 2013.

DOI:10.1016/j.gynor.2013.04.002
PMID:24371692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3862306/
Abstract

•Ovarian cancer patients receiving bevacizumab treatment can experience significant adverse events.•We report a case of vertebral artery dissection associated with bevacizumab treatment.

摘要

•接受贝伐单抗治疗的卵巢癌患者可能会经历严重的不良事件。

•我们报告一例与贝伐单抗治疗相关的椎动脉夹层病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/3862306/2b92bd9a3586/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/3862306/e4a6184fe96f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/3862306/2b92bd9a3586/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/3862306/e4a6184fe96f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c932/3862306/2b92bd9a3586/gr2.jpg

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本文引用的文献

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Incorporation of bevacizumab in the primary treatment of ovarian cancer.贝伐珠单抗在卵巢癌初始治疗中的应用。
N Engl J Med. 2011 Dec 29;365(26):2473-83. doi: 10.1056/NEJMoa1104390.
2
Cerebrovascular events after bevacizumab treatment: an early and severe complication.贝伐珠单抗治疗后的脑血管事件：一种早期且严重的并发症。
Neurocrit Care. 2011 Dec;15(3):421-7. doi: 10.1007/s12028-011-9552-5.
3
Cerebrovascular dissections--a review part I: Spontaneous dissections.脑血管夹层——综述部分 I：自发性夹层。
贝伐单抗用于治疗卵巢癌的极端并发症：来自三级转诊中心的病例系列及文献综述
Ann Transl Med. 2020 Dec;8(24):1687. doi: 10.21037/atm-20-4448.
4
Woven Endobridge device for treatment of dissection-related PICA aneurysm.Woven Endobridge 装置治疗与夹层相关的 PICA 动脉瘤。
Interv Neuroradiol. 2021 Jun;27(3):388-390. doi: 10.1177/1591019920968349. Epub 2020 Oct 18.
5
Vascular Toxicities of Cancer Therapies: The Old and the New--An Evolving Avenue.癌症治疗的血管毒性：新旧情况——一条不断演变的途径
Circulation. 2016 Mar 29;133(13):1272-89. doi: 10.1161/CIRCULATIONAHA.115.018347.
Neurosurgery. 2011 Jan;68(1):242-57; discussion 257. doi: 10.1227/NEU.0b013e3182012323.
4
Bevacizumab toxicities and their management in ovarian cancer.贝伐珠单抗在卵巢癌中的毒性及其处理。
Gynecol Oncol. 2010 Jun;117(3):497-504. doi: 10.1016/j.ygyno.2010.02.021. Epub 2010 Apr 2.
5
Extracranial carotid and vertebral artery dissection: a review.颅外颈动脉和椎动脉夹层：综述
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Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer.贝伐单抗用于铂耐药卵巢癌或腹膜浆液性癌患者的II期研究。
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