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Infused Autograft Absolute Lymphocyte Count Predicts Superior Survival in Diffuse Large B Cell Lymphoma Patients Post-Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation: A Matched Case-Control Study.输注自体移植绝对淋巴细胞计数可预测弥漫性大 B 细胞淋巴瘤患者自体外周血造血干细胞移植后的生存优势：一项匹配病例对照研究。
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本文引用的文献

1
[Relationship between the absolute lymphocyte count before or after autologous hematopoietic stem cell transplantation and the prognosis in patients with non-Hodgkin's lymphoma].
Zhonghua Xue Ye Xue Za Zhi. 2010 Aug;31(8):510-4.
2
Higher infused CD34+ hematopoietic stem cell dose correlates with earlier lymphocyte recovery and better clinical outcome after autologous stem cell transplantation in non-Hodgkin's lymphoma.在非霍奇金淋巴瘤自体干细胞移植后，较高的输注CD34+造血干细胞剂量与更早的淋巴细胞恢复及更好的临床结局相关。
Transfusion. 2009 Sep;49(9):1890-900. doi: 10.1111/j.1537-2995.2009.02202.x. Epub 2009 May 11.
3
Immune reconstitution and implications for immunotherapy following haematopoietic stem cell transplantation.造血干细胞移植后的免疫重建及其对免疫治疗的意义。
Best Pract Res Clin Haematol. 2008 Sep;21(3):579-96. doi: 10.1016/j.beha.2008.06.003.
4
Early lymphocyte recovery predicts superior survival after autologous stem cell transplantation in non-Hodgkin lymphoma: a prospective study.早期淋巴细胞恢复可预测非霍奇金淋巴瘤自体干细胞移植后的卓越生存率：一项前瞻性研究。
Biol Blood Marrow Transplant. 2008 Jul;14(7):807-16. doi: 10.1016/j.bbmt.2008.04.013.
5
Early lymphocyte recovery is a predictive factor for prolonged survival after autologous hematopoietic stem cell transplantation for acute myelogenous leukemia.早期淋巴细胞恢复是急性髓性白血病自体造血干细胞移植后长期生存的一个预测因素。
Leukemia. 2002 Jul;16(7):1311-8. doi: 10.1038/sj.leu.2402503.
6
Early lymphocyte recovery post-autologous haematopoietic stem cell transplantation is associated with better survival in Hodgkin's disease.自体造血干细胞移植后早期淋巴细胞恢复与霍奇金淋巴瘤更好的生存率相关。
Br J Haematol. 2002 Jun;117(3):629-33. doi: 10.1046/j.1365-2141.2002.03478.x.
7
Immune reconstitution after autologous hematopoietic stem cell transplantation.自体造血干细胞移植后的免疫重建
Mayo Clin Proc. 2001 Apr;76(4):407-12. doi: 10.4065/76.4.407.
8
Special considerations for the patient undergoing allogeneic or autologous bone marrow transplantation.接受同种异体或自体骨髓移植患者的特殊注意事项。
Hematol Oncol Clin North Am. 1993 Oct;7(5):961-1002.

淋巴细胞恢复与输注的CD34+细胞剂量：对干细胞自体移植后病程的影响。

Lymphocyte recovery and infused CD34+ cells dose: Effect on the evolution after stem cell autotransplantation.

作者信息

Romero Fernández Esperanza, Bravo Guillermo Montalbán, Gallastegui Rosario Arrieta, De la Rúa Fernández Ana Rodríguez

机构信息

Hematology Department, University Hospital La Paz, Paseo de la Castellana 261, C. P. 28046 Madrid, Spain.

出版信息

Leuk Res Rep. 2013 Jul 15;2(2):54-7. doi: 10.1016/j.lrr.2013.06.002. eCollection 2013.

DOI:10.1016/j.lrr.2013.06.002
PMID:24371781
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3850388/
Abstract

BACKGROUND AND OBJECTIVE

The number of infused CD34+cells (CD34+i) has been associated with absolute lymphocyte count (ALC) and the outcome undergoing autologous hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The study's aim was to analyze the relationship between CD34+i, ALC and prognosis in this patients.

PATIENTS AND METHOD

Medical records of 163 patients receiving HSCT between 2005 and 2012 were reviewed.

RESULTS

We found significant and inversely proportional relationship between the CD34+i and the days required to reach ALC≥500/μl according to the regression line: days=-0.981×number of CD34+i+18.09.

CONCLUSIONS

We have obtained a predictive model of lymphocyte recovery based recovery of CD34+i.

摘要

背景与目的

输注的CD34+细胞数量（CD34+i）与血液系统恶性肿瘤患者接受自体造血干细胞移植（HSCT）时的绝对淋巴细胞计数（ALC）及预后相关。本研究旨在分析此类患者中CD34+i、ALC与预后之间的关系。

患者与方法

回顾了2005年至2012年间163例接受HSCT患者的病历。

结果

根据回归线，我们发现CD34+i与达到ALC≥500/μl所需天数之间存在显著的负相关关系：天数 = -0.981×CD34+i数量 + 18.09。

结论

我们基于CD34+i的恢复情况获得了淋巴细胞恢复的预测模型。