Sequeiros Tamara, García Marta, Montes Melania, Oliván Mireia, Rigau Marina, Colás Eva, de Torres Inés, Morote Juan, Reventós Jaume, Doll Andreas
Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
Biomed Res Int. 2013;2013:283635. doi: 10.1155/2013/283635. Epub 2013 Nov 25.
Prostate cancer (PCa) is the most frequently diagnosed type of cancer in developed countries. The decisive method of diagnosis is based on the results of biopsies, morphologically evaluated to determine the presence or absence of cancer. Although this approach leads to a confident diagnosis in most cases, it can be improved by using the molecular markers present in the tissue. Both miRNAs and proteins are considered excellent candidates for biomarkers in formalin-fixed paraffin-embedded (FFPE) tissues, due to their stability over long periods of time. In the last few years, a concerted effort has been made to develop the necessary tools for their reliable measurement in these types of samples. Furthermore, the use of these kinds of markers may also help in establishing tumor grade and aggressiveness, as well as predicting the possible outcomes in each particular case for the different treatments available. This would aid clinicians in the decision-making process. In this review, we attempt to summarize and discuss the potential use of microRNA and protein profiles in FFPE tissue samples as markers to better predict PCa diagnosis, progression, and response to therapy.
前列腺癌（PCa）是发达国家中最常被诊断出的癌症类型。诊断的决定性方法基于活检结果，通过形态学评估来确定癌症的存在与否。尽管这种方法在大多数情况下能得出可靠的诊断，但利用组织中存在的分子标志物可对其进行改进。由于miRNA和蛋白质在长时间内具有稳定性，它们被认为是福尔马林固定石蜡包埋（FFPE）组织中生物标志物的极佳候选者。在过去几年中，人们齐心协力开发在这类样本中对其进行可靠测量的必要工具。此外，使用这类标志物还可能有助于确定肿瘤分级和侵袭性，以及预测针对每种特定情况的不同可用治疗方法的可能结果。这将有助于临床医生进行决策。在本综述中，我们试图总结和讨论FFPE组织样本中微小RNA和蛋白质谱作为标志物的潜在用途，以更好地预测前列腺癌的诊断、进展及对治疗的反应。
