Khafagi F, Egerton-Vernon J, van Doorn T, Foster W, McPhee I B, Allison R W
J Nucl Med. 1987 Apr;28(4):528-31.
Two cases of familial, malignant, nonfunctional paraganglioma are reported. Uptake of iodine-131 metaiodobenzylguanidine ([131I]MIBG) by the tumors and metastases was demonstrated. In the first case, with multicentric and locally invasive disease, [131I]MIBG correctly localized a right carotid body paraganglioma which had been missed arteriographically. In the second case, with widespread, symptomatic metastatic disease, a therapeutic dose of [131I]MIBG produced palliation of bone pain after the failure of radio- and chemotherapy. Uptake of [131I]MIBG by paragangliomas does not correlate with catecholamine secretory activity. Iodine-131 MIBG should be considered as a therapeutic option in unresectable, malignant paragangliomas which take up this radiopharmaceutical.
报告了两例家族性恶性无功能副神经节瘤。肿瘤和转移灶摄取了碘-131间碘苄胍（[131I]MIBG）。第一例患者患有多中心局部浸润性疾病，[131I]MIBG准确地定位了一例动脉造影未发现的右侧颈动脉体副神经节瘤。第二例患者患有广泛的有症状转移性疾病，在放疗和化疗失败后，治疗剂量的[131I]MIBG缓解了骨痛。副神经节瘤摄取[131I]MIBG与儿茶酚胺分泌活性无关。对于摄取这种放射性药物的不可切除恶性副神经节瘤，应将碘-131 MIBG视为一种治疗选择。
