Hoefnagel C A
Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam.
Eur J Nucl Med. 1991;18(6):408-31. doi: 10.1007/BF02258432.
Apart from its use in endocrinology and rheumatology, therapeutic nuclear medicine is developing rapidly as an additional treatment modality in oncology. Many different specific tumour-seeking radiopharmaceuticals are being applied both for diagnostic scintigraphy and treatment, using multiple routes and mechanisms to target radionuclides at tumours. After a brief introduction of some basic principles of radionuclide targeting, the therapeutic radiopharmaceuticals available are reviewed according to the accumulation site in relation to the cell nucleus; the results of their current clinical use for therapy are also reviewed. The response observed to a number of these applications, the non-invasiveness of the procedure and the relative lack of toxicity and late effects in comparison with chemotherapy and external beam radiotherapy make radionuclide therapy an attractive and realistic alternative in the management of malignant disease, as well as in the treatment of a few benign disorders.
除了在内分泌学和风湿病学中的应用外，治疗性核医学作为肿瘤学中的一种额外治疗方式正在迅速发展。许多不同的特异性肿瘤靶向放射性药物正被应用于诊断性闪烁扫描和治疗，利用多种途径和机制将放射性核素靶向肿瘤。在简要介绍放射性核素靶向的一些基本原理后，根据其相对于细胞核的积聚部位对可用的治疗性放射性药物进行了综述；还综述了它们目前用于治疗的临床结果。与化疗和体外照射放疗相比，观察到的对许多此类应用的反应、该程序的非侵入性以及相对较低的毒性和后期效应，使得放射性核素治疗成为恶性疾病管理以及一些良性疾病治疗中一种有吸引力且切实可行的替代方法。
