Paul Sanchit, Baranya Shrikrishna Suprabha, Suman Ethel, Shenoy Ramya, Rao Arathi
Department of Paedodontics and Preventive Dentistry, Manipal College of Dental Sciences, Manipal University, India.
Int J Paediatr Dent. 2014 Nov;24(6):399-408. doi: 10.1111/ipd.12085. Epub 2013 Dec 25.
Recent systematic reviews on clinical trials comparing the efficacy of chlorhexidine and fluoride varnish found that the evidence was inconclusive and further well-conducted randomized controlled clinical trials were advocated.
To compare the effect of fluoride varnish (F) and Chlorhexidine-thymol varnish (CHX/T) with intensive application regimen on mutans streptococci (MS) levels in human dental plaque.
Seventy-five subjects between 6 and 10 years of age were allocated into three groups: Group 1-F varnish (n = 29); Group 2-CHX/T varnish(n = 29); Group 3-placebo varnish (n = 17) by stratified block randomization. After baseline plaque samples were obtained, varnish application was applied and repeated at an interval of 3 days in each group. Plaque samples were repeated at 48 h, 1 month, and 3 months. The samples were spread over mitis-salivarius-bacitracin (MSB) culture media, and the colony-forming units per ml (CFU) were measured.
In both Groups 1 and 2, Wilcoxon matched-pairs signed-rank test revealed significant differences in log CFU values of MS between baseline and 48 h, baseline and 1 month but no significant difference between baseline and 3 months. An intergroup comparison at different time intervals showed that the difference between three groups was statistically insignificant.
F varnish and CHX/T varnish, with an intensive regimen application have equivocal effect on MS levels in dental plaque.
近期关于比较洗必泰和氟化物清漆疗效的临床试验的系统评价发现，证据尚无定论，因此提倡进一步开展精心设计的随机对照临床试验。
比较氟化物清漆（F）和洗必泰 - 百里酚清漆（CHX/T）强化应用方案对人类牙菌斑中变形链球菌（MS）水平的影响。
将75名6至10岁的受试者通过分层区组随机化分为三组：第1组 - F清漆组（n = 29）；第2组 - CHX/T清漆组（n = 29）；第3组 - 安慰剂清漆组（n = 17）。在获取基线菌斑样本后，每组进行清漆涂抹，并每隔3天重复一次。在48小时、1个月和3个月时重复采集菌斑样本。将样本接种在轻唾 - 杆菌肽（MSB）培养基上，测量每毫升的菌落形成单位（CFU）。
在第1组和第2组中，Wilcoxon配对符号秩检验显示，基线与48小时、基线与1个月之间MS的对数CFU值存在显著差异，但基线与3个月之间无显著差异。不同时间间隔的组间比较显示，三组之间的差异无统计学意义。
F清漆和CHX/T清漆强化应用方案对牙菌斑中MS水平的影响不明确。
