Vitiligo Clinic, Melanosite, New Delhi, India.
Dermatol Surg. 2014 Feb;40(2):169-75. doi: 10.1111/dsu.12394. Epub 2013 Dec 23.
Although leukotrichia in vitiligo is troublesome, no study has been performed with a large number of patients undergoing surgical or medical vitiligo treatment giving importance to its improvement.
To evaluate retrospectively the improvement of leukotrichia after a modified procedure of autologous noncultured epidermal suspension transplantation.
Individuals with stable vitiligo (N = 31) were included, and 42 lesions with leukotrichia were treated. Autologous noncultured epidermal suspension was prepared from split skin graft and transplanted to the dermabraded recipient area using a new modified procedure. Patients were given methylcobalamin and advised to get daily sun exposure after dressing removal. Follow-up ranged from 6 months to 1 year. Retrospective assessment was based on percentage improvement of leukotrichia according to photographs.
There was improvement of leukotrichia in 37 of 42 (88.1%) treated lesions. Improvement was faster in body hairs than pubic hairs and hair on the face and scalp. No significant adverse events were reported.
Although retrograde migration of melanocytes in the improvement of leukotrichia was observed in surgical management of vitiligo, this is the first study with a large number of patients using noncultured epidermal suspension transplantation.
尽管白癜风中的白发令人困扰，但目前尚无研究重视其改善问题，对大量接受手术或医学性白癜风治疗的患者进行评估。
回顾性评估改良自体非培养表皮悬浮移植术改善白发的效果。
纳入稳定期白癜风患者（N=31），共 42 处有白发的皮损接受治疗。采用改良方法从患者的刃厚皮片制备自体非培养表皮悬浮液，移植至磨皮后的受区。患者在去除敷料后，每天接受甲钴胺治疗并进行日光照射。随访时间为 6 个月至 1 年。根据照片评估，评估白发改善的百分比，为回顾性评估。
37 处（88.1%）治疗皮损的白发有改善。体毛的改善速度快于阴毛和面部及头皮毛发。未报告明显的不良反应。
虽然在白癜风的手术治疗中观察到黑素细胞逆行迁移可改善白发，但这是首例采用非培养表皮悬浮移植术治疗大量患者的研究。
