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自体非培养黑素细胞-角质形成细胞移植治疗白癜风:患者选择及展望

Autologous non-cultured melanocyte-keratinocyte transplantation in the treatment of vitiligo: patient selection and perspectives.

作者信息

Bassiouny Dalia, Esmat Samia

机构信息

Department of Dermatology, Kasr El-Ainy Teaching Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt,

出版信息

Clin Cosmet Investig Dermatol. 2018 Oct 26;11:521-540. doi: 10.2147/CCID.S151503. eCollection 2018.

DOI:10.2147/CCID.S151503
PMID:30464567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6208871/
Abstract

Autologous non-cultured melanocyte-keratinocyte transplantation procedure (MKTP) is one of the simplest cellular grafting techniques. Various modifications were done over the years to make the technique easier and more economical which led to its great popularity among dermatologists. Proper patient selection and good technical skills are essential for achieving success with this technique. In this review, different patient-related and procedure-related factors that affect the outcome are discussed. This review may guide dermatologists to select suitable candidates, and explains what to expect in each case and indicates different techniques which can be used. The expected complications and stability of acquired pigmentation, which are an essential part of the pretreatment patient counseling, are also discussed.

摘要

自体非培养黑素细胞-角质形成细胞移植术(MKTP)是最简单的细胞移植技术之一。多年来人们对该技术进行了各种改良,使其更简便、更经济,这也使其在皮肤科医生中广受欢迎。正确选择患者和具备良好的技术技能是该技术取得成功的关键。在这篇综述中,我们讨论了影响治疗结果的不同患者相关因素和手术相关因素。这篇综述可以指导皮肤科医生选择合适的患者,解释每种情况下的预期情况,并介绍可使用的不同技术。我们还讨论了预期并发症以及获得性色素沉着的稳定性,这些都是治疗前患者咨询的重要内容。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b764/6208871/4125c29037dc/ccid-11-521Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b764/6208871/bafd0a46d49e/ccid-11-521Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b764/6208871/4125c29037dc/ccid-11-521Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b764/6208871/bafd0a46d49e/ccid-11-521Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b764/6208871/4125c29037dc/ccid-11-521Fig2.jpg

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JAMA Dermatol. 2018 Mar 1;154(3):301-308. doi: 10.1001/jamadermatol.2017.5795.
2
Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo.稳定期白癜风患者非培养黑素细胞/角质形成细胞悬液自体移植治疗反应的评估。
An Bras Dermatol. 2017 May-Jun;92(3):312-318. doi: 10.1590/abd1806-4841.20175700.
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A single-arm open-label clinical trial of autologous epidermal cell transplantation for stable vitiligo: A 30-month follow-up.
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J Cosmet Dermatol. 2025 Feb;24(2):e16660. doi: 10.1111/jocd.16660. Epub 2024 Nov 7.
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