Morote J, Ruibal A, Pascual C, Palou J, de Torres J A
J Urol. 1987 May;137(5):891-3. doi: 10.1016/s0022-5347(17)44286-8.
We analyzed serum and bone marrow levels of prostatic specific antigen and prostatic acid phosphatase quantified by double antibody radioimmunoassay in 70 patients. Of the patients 36 had prostatic cancer, including 23 with metastatic disease. There was a significant correlation between the serum and bone marrow levels of prostatic specific antigen and prostatic acid phosphatase independently of the metastases (p less than 0.001). No patient with prostatic cancer and positive bone marrow prostatic specific antigen or prostatic acid phosphatase levels had normal serum levels. Quantification of bone marrow prostatic specific antigen and prostatic acid phosphatase does not provide more information than does serum determination.
我们采用双抗体放射免疫分析法对70例患者的血清及骨髓中前列腺特异性抗原和前列腺酸性磷酸酶水平进行了分析。其中36例患者患有前列腺癌，包括23例伴有转移病灶的患者。无论有无转移，血清及骨髓中前列腺特异性抗原和前列腺酸性磷酸酶水平之间均存在显著相关性（p<0.001）。骨髓中前列腺特异性抗原或前列腺酸性磷酸酶水平呈阳性的前列腺癌患者，其血清水平均不正常。与血清测定相比，骨髓中前列腺特异性抗原和前列腺酸性磷酸酶的定量分析并不能提供更多信息。
