Steffens J, Friedmann W, Lobeck H
Eur Urol. 1985;11(2):91-4. doi: 10.1159/000472463.
Metastases of 47 known prostatic carcinomas were subjected to the unlabeled immunoperoxidase procedure to localize prostate acid phosphatase (PAP) and prostate-specific antigen (PSA). PAP was found in 64% and PSA in 78% of bone marrow, lymph node, lung and liver metastases investigated. There was no significant difference between the intensity of staining in primary and metastatic neoplasms. Staining of PAP and PSA was found to be less intense in poorly differentiated metastases of prostatic adenocarcinomas. The data suggest that the demonstration of PAP and PSA is a practical and sensitive test for determining the prostatic origin of a clinically and histologically unclassifiable metastasis.
对47例已知前列腺癌转移灶进行未标记免疫过氧化物酶法，以定位前列腺酸性磷酸酶（PAP）和前列腺特异性抗原（PSA）。在所研究的骨髓、淋巴结、肺和肝转移灶中，64%发现有PAP，78%发现有PSA。原发肿瘤和转移肿瘤的染色强度无显著差异。在前列腺腺癌分化差的转移灶中，PAP和PSA的染色强度较低。数据表明，PAP和PSA的检测是确定临床和组织学上无法分类的转移灶前列腺来源的实用且敏感的检测方法。
