Instituto de Química Orgánica General (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Instituto de Química-Física "Rocasolano" (CSIC), Serrano 119, 28006 Madrid, Spain.
J Chromatogr A. 2014 Jan 24;1326:96-102. doi: 10.1016/j.chroma.2013.12.020. Epub 2013 Dec 16.
For the first time, four commercial ionic liquid columns (SLB-IL59, SLB-IL76, SLB-IL82 and SLB-IL100) for gas chromatography have been comprehensively evaluated in terms of efficiency, polarity and solvation properties. Grob tests and McReynolds constants showed that they were all high-efficiency columns of high polarity, but with low inertness to compounds with hydrogen bonding capabilities. The solvation parameter model was used to characterize the solvation interactions of the four columns in the 80-160°C temperature range. Results revealed that all the ionic liquids studied can be considered moderately hydrogen-bond acid and highly cohesive stationary phases, on which the dominant contributions to retention were the dipolar-type and hydrogen-bond base interactions, while π-π and n-π interactions were barely significant. The SLB-IL59 column provided the best separation of homologs, while the SLB-IL76 and SLB-IL100 columns had the most basic and the most acidic phases, respectively. A principal component analysis for the commonly used stationary phases in capillary GC showed that these commercial ionic liquid columns fill an empty area of the available selectivity space, which clearly enhances the separation capacity of this technique.
首次全面评估了四种商业离子液体色谱柱（SLB-IL59、SLB-IL76、SLB-IL82 和 SLB-IL100）在效率、极性和溶剂化性能方面的性能。Grob 测试和 McReynolds 常数表明，它们都是高效、高极性的柱子，但对具有氢键能力的化合物惰性较低。溶剂化参数模型用于表征四种柱子在 80-160°C 温度范围内的溶剂化相互作用。结果表明，所有研究的离子液体都可以被认为是中等氢键酸和高内聚固定相，在这些固定相中，保留的主要贡献是偶极型和氢键碱相互作用，而 π-π 和 n-π 相互作用几乎没有显著影响。SLB-IL59 柱提供了同系物的最佳分离，而 SLB-IL76 和 SLB-IL100 柱分别具有最碱性和最酸性的相。毛细管 GC 中常用固定相的主成分分析表明，这些商业离子液体柱填补了可用选择性空间的空白区域，这明显增强了该技术的分离能力。
