多形性胶质母细胞瘤硼中子俘获疗法随机临床试验的病例数。
Case numbers for a randomized clinical trial of boron neutron capture therapy for Glioblastoma multiforme.
作者信息
Sander Anja, Wosniok Werner, Gabel Detlef
机构信息
Kompetenzzentrum Klinische Studien KKS, Bremen, Germany; Cooperative Center Medicine, University of Bremen, Bremen, Germany.
Department of Chemistry, University of Bremen, Bremen, Germany; Cooperative Center Medicine, University of Bremen, Bremen, Germany; School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany.
出版信息
Appl Radiat Isot. 2014 Jun;88:16-9. doi: 10.1016/j.apradiso.2013.11.092. Epub 2013 Dec 4.
Boron neutron capture therapy (BNCT) with Na2B12H11SH (BSH) or p-dihydroxyborylphenylalanine (BPA), and with a combination of both, was compared to radiotherapy with temozolomide, and the number of patients required to show statistically significant differences between the treatments was calculated. Whereas arms using BPA require excessive number of patients in each arm, a two-armed clinical trial with BSH and radiotherapy plus temozolomide is feasible.
将使用Na2B12H11SH（BSH）或对二羟基硼基苯丙氨酸（BPA）以及两者联合的硼中子俘获疗法（BNCT）与替莫唑胺放疗进行比较，并计算出各治疗组间显示出统计学显著差异所需的患者数量。鉴于使用BPA的各治疗组需要过多患者，一项关于BSH与放疗加替莫唑胺的双臂临床试验是可行的。
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