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巴基斯坦白沙瓦育龄农村妇女锌缺乏症的患病率

Prevalence of zinc deficiency among rural women during childbearing age in Peshawar, Pakistan.

作者信息

Akhtar Tasleem, Khan Mir Hassan, Hussain Hamid, Nazli Rubina, Lutfullah Ghosia

机构信息

PMRC Research Centre, Khyber Medical College, Peshawar, Pakistan.

Department of Biochemistry, Peshawar Medical College, Peshawar, Pakistan.

出版信息

Pak J Pharm Sci. 2014 Jan;27(1):173-7.

Abstract

Zinc deficiency is a commonly reported health problem throughout the world. This cross sectional survey was conducted in rural Peshawar with an aim to estimate the prevalence of zinc deficiency in women of child bearing age and find its association with age, marital, pregnancy status and parity. Data was collected from 353 women age 15-45 years. EPI INFO version 6.04 was used for data analysis. Overall 98 (27.8 %) women were zinc deficient (<80 μg/dL) while 31 (8.8%) had severe zinc deficiency (<50μg/dL.). Mean zinc level was found to increase gradually with the increase in the age up to 40 years and then starts decreasing significantly beyond this age. A significant decrease (p<0.03) in zinc concentration was found in married as compared to unmarried women. Out of 31 female with severe zinc deficiency, 23 (74.2%) were pregnant. Pregnant women in second (OR (CI) 3.36 (1.52-7.44) p<0.0008) and third ((OR (CI) 3.73 (1.91-7.30) p<0.00002) trimester were 3.4 & 3.7 times, respectively more zinc deficient as compared to control women. Mean zinc levels were significantly lower in women having no children versus women with 1-5 numbers of children. This study concludes that severe zinc deficiency especially prevalent in pregnant women needs urgent correction through food supplementation.

摘要

锌缺乏是全球普遍报道的一个健康问题。这项横断面调查在白沙瓦农村地区开展,旨在估算育龄妇女中锌缺乏的患病率,并找出其与年龄、婚姻状况、妊娠状态及胎次的关联。研究收集了353名年龄在15至45岁之间女性的数据。采用EPI INFO 6.04版本进行数据分析。总体而言,98名(27.8%)女性存在锌缺乏(<80微克/分升),而31名(8.8%)有严重锌缺乏(<50微克/分升)。锌平均水平在40岁之前随年龄增长逐渐升高,之后在此年龄之后开始显著下降。与未婚女性相比,已婚女性的锌浓度显著降低(p<0.03)。在31名严重锌缺乏的女性中,23名(74.2%)为孕妇。妊娠中期(比值比(置信区间)3.36(1.52 - 7.44),p<0.0008)和妊娠晚期(比值比(置信区间)3.73(1.91 - 7.30),p<0.00002)的孕妇锌缺乏程度分别是对照女性的3.4倍和3.7倍。未育女性的平均锌水平显著低于育有1至5个孩子的女性。本研究得出结论,严重锌缺乏,尤其是在孕妇中普遍存在,需要通过食物补充剂进行紧急纠正。

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