氯胺酮对大鼠脑不同区域胆囊收缩素、生长抑素、P物质及促甲状腺激素释放激素的影响。
Effects of ketamine on the cholecystokinin, somatostatin, substance P, and thyrotropin releasing hormone in discrete regions of rat brain.
作者信息
Pongdhana K, Ogawa N, Hirose Y, Ono T, Kosaka F, Mori A
出版信息
Neurochem Res. 1987 Jan;12(1):73-7. doi: 10.1007/BF00971367.
PMID:2437471
Abstract
Intraperitoneal injection of ketamine (100 mg/kg body weight) significantly reduces the levels of cholecystokinin (CCK), somatostatin (SRIF), and substance P (SP)-like immunoreactivity in various regions of rat brain. No significant change in thyrotropin releasing hormone (TRH)-like immunoreactivity was observed. Neuropeptide systems may be involved in the neuropharmacologic effects of ketamine.
摘要
腹腔注射氯胺酮（100毫克/千克体重）可显著降低大鼠脑不同区域胆囊收缩素（CCK）、生长抑素（SRIF）和P物质（SP）样免疫反应性水平。促甲状腺激素释放激素（TRH）样免疫反应性未观察到显著变化。神经肽系统可能参与了氯胺酮的神经药理作用。
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