Wang Fang, Wang Peng, Wang Bin, Fu Zheng-Ju, Yuan Ying, Yan Sheng-Li, Zhao Wen-Juan, Wang Yan-Gang
Department of Endocrinology, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
Tumour Biol. 2014 Mar;35(3):2723-8. doi: 10.1007/s13277-013-1359-x. Epub 2013 Dec 28.
TP53 Arg72Pro polymorphism has been proposed to have some effects on host's susceptibility to cancer. Several studies were published to assess the association between TP53 Arg72Pro polymorphism and thyroid carcinoma, but they reported controversial results. We performed a systemic review and meta-analysis to assess the association between TP53 Arg72Pro polymorphism and thyroid carcinoma. Odds ratio (OR) with 95% confidence interval (95% CI) was used to assess the association. Fourteen individual studies with 3,483 subjects were finally included into the meta-analysis. Overall, there was an obvious association between TP53 Arg72Pro polymorphism and thyroid carcinoma under the recessive model (ProPro vs. ArgArg/ArgPro, OR = 2.02, 95% CI 1.13 to 3.62, P = 0.02). Subgroup analysis by race showed that TP53 Arg72Pro polymorphism was associated with thyroid carcinoma in Caucasians (ProPro vs. ArgArg/ArgPro, OR = 2.31, 95% CI 1.08 to 4.93, P = 0.03). Subgroup analysis by histological type showed that TP53 Arg72Pro polymorphism was not associated with a risk of different types of thyroid carcinoma. In summary, the meta-analysis suggests that TP53 Arg72Pro polymorphism is associated with thyroid carcinoma risk in Caucasians. Besides, more studies with large sample size are needed to further assess the associations above.
TP53基因第72位密码子精氨酸（Arg）突变为脯氨酸（Pro）的多态性被认为对宿主患癌易感性有一定影响。已有多项研究发表，旨在评估TP53基因Arg72Pro多态性与甲状腺癌之间的关联，但结果存在争议。我们进行了一项系统综述和荟萃分析，以评估TP53基因Arg72Pro多态性与甲状腺癌之间的关联。采用比值比（OR）及95%置信区间（95%CI）评估两者的关联强度。最终，14项涉及3483名受试者的独立研究被纳入荟萃分析。总体而言，在隐性模型下（ProPro与ArgArg/ArgPro相比），TP53基因Arg72Pro多态性与甲状腺癌之间存在显著关联（OR = 2.02，95%CI为1.13至3.62，P = 0.02）。按种族进行的亚组分析显示，在白种人中TP53基因Arg72Pro多态性与甲状腺癌有关（ProPro与ArgArg/ArgPro相比；OR = 2.31，95%CI为1.08至4.93，P = 0.03）。按组织学类型进行亚组分析显示，TP53基因Arg72Pro多态性与不同类型甲状腺癌的发病风险无关。综上所述, 荟萃分析表明TP53基因Arg72Pro多态性与白种人患甲状腺癌的风险有关, 此外, 需要更多大样本研究来进一步评估上述关联关系
