TP53基因密码子72多态性与急性髓系白血病易感性的关联：基于荟萃分析的证据
Association Between TP53 Gene Codon 72 Polymorphism and Acute Myeloid Leukemia Susceptibility: Evidence Based on a Meta-Analysis.
作者信息
Ruan Xiao-Lan, Li Sheng, Geng Peiliang, Zeng Xian-Tao, Yu Guo-Zheng, Meng Xiang-Yu, Gao Qing-Ping, Ao Xu-Bin
机构信息
Department of Hematology, Targeted Biotherapy Key Laboratory of Ministry of Education, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland).
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China (mainland).
出版信息
Med Sci Monit. 2015 Oct 9;21:3048-53. doi: 10.12659/MSM.894625.
BACKGROUND
Many studies have reported that the p53 codon 72 polymorphism is associated with acute myeloid leukemia (AML) susceptibility; however, the conclusions are inconsistent. Therefore, we performed this meta-analysis to obtain a more precise result.
MATERIAL AND METHODS
We searched PubMed to identify relevant studies, and 6 published case-control studies were retrieved, including 924 AML patients and 3832 controls. Odds ratio (OR) with corresponding 95% confidence interval (95%CI) was applied to assess the association between p53 codon 72 polymorphism and AML susceptibility. The meta-analysis was performed with Comprehensive Meta-Analysis software, version 2.2.
RESULTS
Overall, no significant association between p53 codon 72 polymorphism and AML susceptibility was found in this meta-analysis (Pro vs. Arg: OR=0.94, 95%CI=0.81-1.10; Pro/Pro vs. Arg/Arg: OR=0.93, 95%CI=0.71-1.22; Arg/Pro vs. Arg/Arg: OR=0.79, 95%CI=0.55-1.13; (Pro/Pro + Arg/Pro) vs. Arg/Arg: OR=0.84, 95%CI=0.62-1.13; Pro/Pro vs. (Arg/Arg + Arg/Pro): OR=1.06, 95%CI=0.83-1.35). Similar results were also found in stratified analysis according to ethnicity and source of controls.
CONCLUSIONS
Our meta-analysis demonstrates that p53 codon 72 polymorphism may not be a risk factor for AML, which should be verified in future studies.
背景
许多研究报告称，p53基因第72位密码子多态性与急性髓系白血病（AML）易感性相关；然而，结论并不一致。因此，我们进行了这项荟萃分析以获得更精确的结果。
材料与方法
我们检索了PubMed以确定相关研究，共检索到6项已发表的病例对照研究，包括924例AML患者和3832例对照。采用比值比（OR）及相应的95%置信区间（95%CI）来评估p53基因第72位密码子多态性与AML易感性之间的关联。使用Comprehensive Meta-Analysis软件2.2版进行荟萃分析。
结果
总体而言，在这项荟萃分析中未发现p53基因第72位密码子多态性与AML易感性之间存在显著关联（脯氨酸（Pro）与精氨酸（Arg）：OR = 0.94，95%CI = 0.81 - 1.10；Pro/Pro与Arg/Arg：OR = 0.93，95%CI = 0.71 - 1.22；Arg/Pro与Arg/Arg：OR = 0.79，95%CI = 0.55 - 1.13；（Pro/Pro + Arg/Pro）与Arg/Arg：OR = 0.84，95%CI = 0.62 - 1.13；Pro/Pro与（Arg/Arg + Arg/Pro）：OR = 1.06，95%CI = 0.83 - 1.35）。根据种族和对照来源进行的分层分析也得到了类似结果。
结论
我们的荟萃分析表明，p53基因第72位密码子多态性可能不是AML的危险因素，这一点有待未来研究加以验证。
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