Cuckle H, Wald N
Prenat Diagn. 1987 Feb;7(2):91-9. doi: 10.1002/pd.1970070205.
Using information derived from the voluntary system of notification of congenital malformations in England and Wales, the birth prevalence of anencephaly and spina bifida was estimated to have declined by 80 per cent from 31.5 to 6.2 per 10,000 between 1964-1972 and 1985. Over the same period, notified terminations of pregnancy with a suspected fetal central nervous system abnormality increased from less than 1 per cent to 56 per cent of neural tube defect births and central nervous system terminations combined, accounting for 31 per cent of the decline in births. Routinely collected national statistics provide a method for monitoring the impact of screening for open neural tube defects. However because they are incomplete and lack detail an alternative method of monitoring is needed. This paper includes an outline of such a method, together with the results of a pilot study designed to assess the feasibility of monitoring screening in the Oxford Region.
利用从英格兰和威尔士先天性畸形自愿报告系统获得的信息，据估计无脑儿和脊柱裂的出生患病率在1964年至1972年期间至1985年间从每10000例中的31.5例降至6.2例，下降了80%。在同一时期，报告的怀疑有胎儿中枢神经系统异常的妊娠终止数从不到1%增加到神经管缺陷出生数和中枢神经系统妊娠终止数总和的56%，占出生数下降的31%。常规收集的全国统计数据提供了一种监测开放性神经管缺陷筛查影响的方法。然而，由于这些数据不完整且缺乏细节，需要一种替代的监测方法。本文概述了这样一种方法，以及一项旨在评估牛津地区监测筛查可行性的试点研究结果。
