NF-κB 调节中的 IκB 激酶复合物及其作用。
The IκB kinase complex in NF-κB regulation and beyond.
机构信息
Max Delbrück Center for Molecular Medicine, Berlin, Germany.
出版信息
EMBO Rep. 2014 Jan;15(1):46-61. doi: 10.1002/embr.201337983. Epub 2013 Dec 27.
Abstract
The IκB kinase (IKK) complex is the signal integration hub for NF-κB activation. Composed of two serine-threonine kinases (IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ), the IKK complex integrates signals from all NF-κB activating stimuli to catalyze the phosphorylation of various IκB and NF-κB proteins, as well as of other substrates. Since the discovery of the IKK complex components about 15 years ago, tremendous progress has been made in the understanding of the IKK architecture and its integration into signaling networks. In addition to the control of NF-κB, IKK subunits mediate the crosstalk with other pathways, thereby extending the complexity of their biological function. This review summarizes recent advances in IKK biology and focuses on emerging aspects of IKK structure, regulation and function.
摘要
IKK 激酶（IKK）复合物是 NF-κB 激活的信号整合枢纽。该复合物由两个丝氨酸/苏氨酸激酶（IKKα 和 IKKβ）和调节亚基 NEMO（也称为 IKKγ）组成，整合来自所有 NF-κB 激活刺激的信号，以催化各种 IκB 和 NF-κB 蛋白以及其他底物的磷酸化。自大约 15 年前发现 IKK 复合物成分以来，人们在理解 IKK 结构及其整合到信号网络方面取得了巨大进展。除了 NF-κB 的控制之外，IKK 亚基还介导与其他途径的串扰，从而扩展了其生物学功能的复杂性。本综述总结了 IKK 生物学的最新进展，并重点介绍了 IKK 结构、调节和功能的新兴方面。
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