聚放线菌素 1 的合成：两个设计的蒽酮作为灵活双 C-糖基化的有效平台。
Synthesis of the pluramycins 1: two designed anthrones as enabling platforms for flexible bis-C-glycosylation.
机构信息
Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8551 (Japan) http://www.chemistry.titech.ac.jp/∼org_synth/
出版信息
Angew Chem Int Ed Engl. 2014 Jan 27;53(5):1258-61. doi: 10.1002/anie.201308016. Epub 2013 Dec 16.
Two effective tricyclic platforms are reported for the installation of the two constituent sugars, L-vancosamine and D-angolosamine, in a regio- and stereoselective manner for the synthesis of the pluramycin class of bis-C-glycoside antitumor antibiotics. Two complementary protocols are now available that differ in the order in which the two sugar moieties are installed. Sc(OTf)3 was effective as the Lewis acid.
现报道了两种有效的三环骨架平台，用于以区域和立体选择性方式安装两个组成糖 L-万古霉素胺和 D-安吉洛霉素，以合成多柔比星类双 C-糖苷抗肿瘤抗生素。现在有两种互补的方案，它们在安装两个糖部分的顺序上有所不同。Sc(OTf)3 作为路易斯酸是有效的。
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