(-)-普尔沃霉素C24-C40片段的对映选择性合成。
An enantioselective synthesis of the C24-C40 fragment of (-)-pulvomycin.
作者信息
Börding Sandra, Bach Thorsten
机构信息
Lehrstuhl für Organische Chemie I, Technische Universität München, 85747 Garching, Germany.
出版信息
Chem Commun (Camb). 2014 May 18;50(38):4901-3. doi: 10.1039/c4cc01338g.
PMID:24691561
Abstract
The C24-C40 fragment of (-)-pulvomycin was prepared in enantiomerically pure form using a concise synthesis method (15 linear steps from D-fucose, 6.8% overall yield) featuring a diastereoselective addition to an aldehyde, a β-selective glycosylation and a Stille cross-coupling as the key steps.
摘要
使用一种简洁的合成方法（以D-岩藻糖为原料经15步线性反应，总收率6.8%）以对映体纯的形式制备了（-）-普尔沃霉素的C24 - C40片段，该方法的关键步骤包括向醛的非对映选择性加成、β-选择性糖基化和Stille交叉偶联。
Zotero 插件