Hong K W, Lee W S, Rhim B Y
Physiol Behav. 1987;39(4):535-9. doi: 10.1016/0031-9384(87)90386-6.
Upon surgical removal of olfactory bulbs, by the 8th to 10th day after the surgery muricidal behavior has been demonstrated in 75.4% of rats. In the homogenates of forebrain obtained from rats demonstrating muricidal behavior, levels of noradrenaline, 5-hydroxytryptamine and their metabolites (i.e., 3-methoxy-4-hydroxyphenylglycol sulfate and 5-hydroxyindoleacetic acid) were not changed. However, the fractional turnover rate of noradrenaline in the forebrain of the olfactory bulbectomized rats was significantly decreased without alterations in the metabolism of 5-hydroxytryptamine when compared to that of the sham rats. The muricidal behavior and the aggressiveness were suppressed by antagonists of alpha 2-adrenoceptors (yohimbine, idazoxan and rauwolscine), but not by the alpha 1-adrenoceptor antagonist (corynanthine). Furthermore, upon administration of yohimbine or idazoxan to rats demonstrating the muricidal behavior, the level of noradrenaline in the homogenates of forebrain was decreased while that of 3-methoxy-4-hydroxyphenylglycol sulfate was increased. The maximum binding capacity (Bmax) of [3H]yohimbine to the forebrain membranes obtained from the olfactory bulbectomized rats was significantly higher than that from the sham rats without demonstrating any differences in dissociation constants (Kd) between the two brain membranes. Based on these results, it was suggested that olfactory bulbectomy has caused some functional changes in central alpha 2-adrenoceptors.
在手术切除嗅球后，术后第8至10天，75.4%的大鼠表现出杀鼠行为。在表现出杀鼠行为的大鼠的前脑匀浆中，去甲肾上腺素、5-羟色胺及其代谢产物（即3-甲氧基-4-羟基苯乙二醇硫酸盐和5-羟基吲哚乙酸）的水平没有变化。然而，与假手术大鼠相比，嗅球切除大鼠前脑去甲肾上腺素的分数周转率显著降低，而5-羟色胺的代谢没有改变。α2-肾上腺素能受体拮抗剂（育亨宾、咪唑克生和萝芙辛）可抑制杀鼠行为和攻击性，但α1-肾上腺素能受体拮抗剂（育亨宾碱）则不能。此外，给表现出杀鼠行为的大鼠注射育亨宾或咪唑克生后，前脑匀浆中去甲肾上腺素水平降低，而3-甲氧基-4-羟基苯乙二醇硫酸盐水平升高。[3H]育亨宾与嗅球切除大鼠前脑膜的最大结合容量（Bmax）显著高于假手术大鼠，且两种脑膜的解离常数（Kd）没有差异。基于这些结果，提示嗅球切除引起了中枢α2-肾上腺素能受体的一些功能变化。
