Leonard B E, O'Connor W T
Pharmacology Department, University College, Galway, Republic of Ireland.
Neuropsychobiology. 1987;18(3):118-21. doi: 10.1159/000118404.
The chronic effects of mianserin and two of its major metabolites on the behaviour of olfactory bulbectomized rats in the 'open field' apparatus were studied. When these compounds were tested at the same dose, only the parent compound was active in attenuating the hypermotility which the bulbectomized rat exhibited under these experimental conditions. Changes in the concentrations of noradrenaline and 3-methoxy-4-hydroxyphenylglycol (MHPG) were also determined in the amygdaloid cortex and mid-brain regions of the sham-operated and lesioned rats. Only mianserin reversed the reduction in the noradrenaline concentration which occurred in the amygdaloid cortex following bulbectomy; the changes in noradrenaline or MHPG in the mid-brain were not correlated with this behavioural effect of mianserin.
研究了米安色林及其两种主要代谢产物对嗅球切除大鼠在“旷场”装置中行为的慢性影响。当以相同剂量测试这些化合物时，只有母体化合物能有效减轻嗅球切除大鼠在这些实验条件下表现出的运动亢进。还测定了假手术和损伤大鼠杏仁核皮质和中脑区域去甲肾上腺素和3-甲氧基-4-羟基苯乙二醇（MHPG）浓度的变化。只有米安色林能逆转嗅球切除后杏仁核皮质中去甲肾上腺素浓度的降低；中脑去甲肾上腺素或MHPG的变化与米安色林的这种行为效应无关。
