Bowser-Finn R A, Kahan L, Larson F C, Traver M I
Tumour Biol. 1986;7(5-6):343-52.
Previous studies have shown that fast homoarginine-sensitive alkaline phosphatase (FHAP) is roughly equivalent to CEA (Roche) as a marker in colon cancer. The present study compares FHAP with CEA-EIA (Abbott) as a marker in cancer of the colon, breast, lung, ovary, uterus, skin, and lymph nodes. Comparison is made with regard to sensitivity, specificity, predictive value of a positive test, and diagnostic efficiency. It was determined that FHAP and CEA-EIA were comparable as markers for cancers of the colon, breast, and lung. FHAP was more sensitive and specific and had a higher predictive value and diagnostic efficiency for cancers of the ovary, uterus, skin, and lymph nodes.
先前的研究表明，快速高精氨酸敏感性碱性磷酸酶（FHAP）作为结肠癌的标志物，大致等同于癌胚抗原（罗氏公司）。本研究将FHAP与癌胚抗原酶免疫分析（雅培公司）作为结肠癌、乳腺癌、肺癌、卵巢癌、子宫癌、皮肤癌和淋巴结癌的标志物进行比较。比较内容包括敏感性、特异性、阳性检测预测值和诊断效率。结果确定，FHAP和癌胚抗原酶免疫分析作为结肠癌、乳腺癌和肺癌的标志物具有可比性。FHAP对卵巢癌、子宫癌、皮肤癌和淋巴结癌更敏感、更具特异性，且具有更高的预测值和诊断效率。
