Larson F C, Kahan L, Tormey D C, Davis T E
J Clin Oncol. 1984 May;2(5):457-61. doi: 10.1200/JCO.1984.2.5.457.
The diagnostic value of a recently described cancer marker, fast homoarginine-sensitive alkaline phosphatase ( FHAP ), was compared with the established marker, carcinoembryonic antigen (CEA), in the diagnosis of colon cancer. Comparisons were made with respect to sensitivity, specificity, predictive value of a positive result, and efficiency. An upper limit of normal of 2.1 units/L was assumed for FHAP , based on earlier studies. Two values for the upper limit of normal for CEA were tested: 2.5 ng/mL and 5.0 ng/mL. When 2.5 ng/mL was used as the upper limit of normal for CEA, FHAP was less sensitive, more specific, and had a higher predictive value. The diagnostic efficiency was not significantly different. When the upper limit of normal for CEA was set at 5.0 ng/mL, the two tests were roughly equal in sensitivity, specificity, predictive value, and diagnostic efficiency.
在结肠癌诊断中，将一种最近描述的癌症标志物——快速高精氨酸敏感碱性磷酸酶（FHAP）的诊断价值与已确立的标志物癌胚抗原（CEA）进行了比较。比较了它们在敏感性、特异性、阳性结果预测值和效率方面的差异。根据早期研究，假定FHAP的正常上限为2.1单位/升。对CEA的两个正常上限值进行了测试：2.5纳克/毫升和5.0纳克/毫升。当将2.5纳克/毫升用作CEA的正常上限时，FHAP的敏感性较低、特异性较高且具有更高的预测值。诊断效率无显著差异。当CEA的正常上限设定为5.0纳克/毫升时，两种检测在敏感性、特异性、预测值和诊断效率方面大致相当。
