Hörmann K
Scand Audiol Suppl. 1986;26:47-8.
Improvement of the rheological quality of circulating blood is an important factor in pharmacological treatment of inner disorders. Diminution of blood viscosity by increased fluidity of red blood cells and hemodilution was studied in two patient groups, one treated by pentoxifylline per os (Trental 400, Höchst) and dextran infusions, the other one by dextran infusions only. The dextran effect is a short-term hemodilution, i.e. decreased viscosity is identical to hematocrit reduction. Long term, however, there is a significant increased viscosity in the dextran group. A significant constant effect on blood viscosity is warranted by pentoxifylline. Oral administration of this drug prevents the long-term blood thickening effect of dextran and leads to a permanent improvement of microcirculation.
改善循环血液的流变学性质是内科疾病药物治疗中的一个重要因素。在两组患者中研究了通过增加红细胞流动性和血液稀释来降低血液粘度，一组口服己酮可可碱（曲克芦丁400，赫斯特公司）并输注右旋糖酐进行治疗，另一组仅输注右旋糖酐。右旋糖酐的作用是短期血液稀释，即粘度降低与血细胞比容降低相同。然而，从长期来看，右旋糖酐组的粘度显著增加。己酮可可碱对血液粘度有显著的持续作用。口服该药可防止右旋糖酐的长期血液浓缩作用，并导致微循环的永久性改善。
