Department of Pediatric Pulmonology, University Medical Centre Utrecht, Utrecht, The Netherlands ; Department of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands ; Centre for Molecular and Cellular Intervention, University Medical Centre Utrecht, Utrecht, The Netherlands.
Department of Pediatric Pulmonology, University Medical Centre Utrecht, Utrecht, The Netherlands.
PLoS One. 2013 Dec 23;8(12):e82869. doi: 10.1371/journal.pone.0082869. eCollection 2013.
Regular moderate exercise has been suggested to exert anti-inflammatory effects and improve immune effector functions, resulting in reduced disease incidence and viral infection susceptibility. Whether regular exercise also affects bacterial infection susceptibility is unknown. The aim of this study was to investigate whether regular voluntary exercise wheel running prior to a pulmonary infection with bacteria (P. aeruginosa) affects lung bacteriology, sickness severity and phagocyte immune function in mice. Balb/c mice were randomly placed in a cage with or without a running wheel. After 28 days, mice were intranasally infected with P. aeruginosa. Our study showed that regular exercise resulted in a higher sickness severity score and bacterial (P. aeruginosa) loads in the lungs. The phagocytic capacity of monocytes and neutrophils from spleen and lungs was not affected. Although regular moderate exercise has many health benefits, healthy mice showed increased bacterial (P. aeruginosa) load and symptoms, after regular voluntary exercise, with perseverance of the phagocytic capacity of monocytes and neutrophils. Whether patients, suffering from bacterial infectious diseases, should be encouraged to engage in exercise and physical activities with caution requires further research.
经常适度的运动被认为具有抗炎作用，并能改善免疫效应功能，从而降低疾病发生率和病毒感染易感性。然而，经常运动是否也会影响细菌感染的易感性尚不清楚。本研究旨在探讨在肺部细菌（铜绿假单胞菌）感染前进行有规律的自愿轮式跑步运动是否会影响小鼠的肺部细菌学、疾病严重程度和吞噬细胞免疫功能。将 Balb/c 小鼠随机分为有或无跑步轮的笼子中。28 天后，小鼠经鼻腔感染铜绿假单胞菌。我们的研究表明，经常运动导致更高的疾病严重程度评分和肺部细菌（铜绿假单胞菌）负荷。来自脾脏和肺部的单核细胞和中性粒细胞的吞噬能力不受影响。尽管经常适度的运动有许多健康益处，但健康的小鼠在进行有规律的自愿运动后，其肺部的细菌（铜绿假单胞菌）负荷和症状增加，单核细胞和中性粒细胞的吞噬能力保持不变。患有细菌性传染病的患者是否应该谨慎地鼓励他们进行运动和体育活动，这需要进一步的研究。
