Zverkov I V, Vinogradov V A, Bulgakov S A, Smagin V G, Shcherbakova N V
Ter Arkh. 1987;59(2):48-53.
The distribution of gastrin-, gamma-endorphin and somatostatin-producing cells in antral and duodenal mucosa was studied in biopsies from 26 patients with duodenal ulcer and from 13 controls by the immunohistochemical (PAP) method. The number of antral somatostatin-producing cells after dalargin treatment was significantly higher in comparison with controls and patients treated with antacids plus atropine. These changes may be connected with the antiulcer activity of dalargin, a new opioid peptide drug.
采用免疫组织化学（PAP）法，对26例十二指肠溃疡患者和13例对照者的活检标本进行研究，观察胃窦和十二指肠黏膜中胃泌素、γ-内啡肽和生长抑素产生细胞的分布。与对照组及使用抗酸剂加阿托品治疗的患者相比，使用达乐argin治疗后的胃窦生长抑素产生细胞数量显著增加。这些变化可能与新型阿片肽类药物达乐argin的抗溃疡活性有关。
