Zverkov I V, Vinogradov V A, Smagin V G
Biull Eksp Biol Med. 1983 Oct;96(10):32-4.
Immunohistochemical staining with the use of peroxidase-antiperoxidase was applied to study cells producing gamma- and alpha-endorphines in the gastric antral mucosa in duodenal ulcer. The cells producing gamma-endorphines were discovered to be mainly located in the epithelium of the cervical and upper third of the pyloric glands and to be alike G-cells producing gastrin. The cells producing alpha-endorphine were found both in the epithelium of the upper third of the gastric pyloric glands and in the gastric mucosa lamina proper. In peptic ulcer, there was an almost two-fold increase in the amount of gamma-endorphine-producing cells and diminution of epithelial endocrine cells producing alpha-endorphine.
采用过氧化物酶-抗过氧化物酶免疫组织化学染色法，研究十二指肠溃疡患者胃窦黏膜中产生γ-内啡肽和α-内啡肽的细胞。发现产生γ-内啡肽的细胞主要位于幽门腺颈部和上三分之一的上皮细胞中，与产生胃泌素的G细胞相似。产生α-内啡肽的细胞在胃幽门腺上三分之一的上皮细胞和胃黏膜固有层中均有发现。在消化性溃疡中，产生γ-内啡肽的细胞数量几乎增加了两倍，而产生α-内啡肽的上皮内分泌细胞数量减少。
