Liu Yeqiang, Jin Cheng, Xing Aijun, Liu Xiurong, Chen Shuohua, Li Dongqing, Feng Ping, Liu Jinquan, Li Zhiguo, Wu Shouling
The General Hospital of Tianjin Medical University, Tianjin, China ; The Kailuan Hospital, Hebei United University, Tangshan, China.
The Kailuan Hospital, Hebei United University, Tangshan, China.
PLoS One. 2013 Dec 23;8(12):e84712. doi: 10.1371/journal.pone.0084712. eCollection 2013.
To prospectively investigate the association between serum uric acid (SUA) level and incidence of impaired fasting glucose (IFG) in adult Chinese.
We evaluated 13,328 women and 41,350 men without diabetes and IFG. The participants were classified into quintile according to baseline level of SUA. Data were analyzed to examine the association between SUA levels and the incidence of IFG. We used Cox regression models to estimate the relative risk of IFG after adjusting for known risk factors.
For men, the second quintile of SUA has the lowest cumulative incidence of IFG (29.9%); the fifth quintile of SUA has the highest cumulative incidence of IFG (35.6%). After corrected with Cox regression, the first quartile and the fourth quartile have higher cumulative incidence of IFG than the second quintile, with the HR of 1.11(1.05-1.17) and 1.07(1.01-1.13), respectively. For women, the first quartile of SUA has the lowest cumulative incidence of IFG (20.7%), while the fifth quintile of SUA has the highest cumulative incidence of IFG (30.0%). However, there is no significant difference in IFG between different quintile after adjusted with Cox regression.
The results of this prospective study suggest that there is a higher risk of developing IFG in association with low or high SUA concentrations for men. These relationships were independent of other known risk factors. There is no significant correlation in the risk of developing IFG in association with SUA concentrations for women. Analyses excluding participants with hypertension or with hyperlipidemia and analyses with participants stratified by age reached similar conclusion.
前瞻性研究中国成年人血清尿酸（SUA）水平与空腹血糖受损（IFG）发生率之间的关联。
我们评估了13328名女性和41350名无糖尿病和IFG的男性。参与者根据SUA基线水平分为五等份。分析数据以检验SUA水平与IFG发生率之间的关联。我们使用Cox回归模型在调整已知风险因素后估计IFG的相对风险。
对于男性，SUA的第二个五分位数的IFG累积发生率最低（29.9%）；SUA的第五个五分位数的IFG累积发生率最高（35.6%）。经Cox回归校正后，第一个四分位数和第四个四分位数的IFG累积发生率高于第二个五分位数，HR分别为1.11（1.05 - 1.17）和1.07（1.01 - 1.13）。对于女性，SUA的第一个四分位数的IFG累积发生率最低（20.7%），而SUA的第五个五分位数的IFG累积发生率最高（30.0%）。然而，经Cox回归调整后，不同五分位数之间的IFG无显著差异。
这项前瞻性研究的结果表明，男性SUA浓度过低或过高与发生IFG的风险较高有关。这些关系独立于其他已知风险因素。女性SUA浓度与发生IFG的风险无显著相关性。排除高血压或高脂血症参与者的分析以及按年龄分层的参与者分析得出了类似的结论。
