Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K
Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, Suita-shi, Osaka, Japan.
Eur J Epidemiol. 2003;18(6):523-30. doi: 10.1023/a:1024600905574.
We examined the association of serum uric acid (SUA) with development of hypertension (blood pressure > or = 140/90 mmHg and/or medication for hypertension) and impaired fasting glucose (IFG) (a fasting plasma glucose level 6.1-6.9 mmol/l) or Type II (non-insulin-dependent) diabetes (a fasting plasma glucose level > or = 7.0 mmol/l and/or medication for diabetes) over a 6-year follow-up among 2310 Japanese male office workers aged 35-59 years who did not have hypertension, IFG, Type II diabetes, or past history of cardiovascular disease at study entry. After controlling for potential predictors of hypertension and diabetes, the relative risk for hypertension compared with quintile 1 of SUA level was 1.27 [95% confidence interval (CI): 1.00-1.62] for quintile 2, 1.34 (95% CI: 1.08-1.74) for quintile 3, 1.48 (95% CI: 1.18-1.89) for quintile 4, and 1.58 (95% CI: 1.26-1.99) for quintile 5 (p for trend <0.001). The respective multivariate-adjusted relative risks for IFG or Type II diabetes compared with quintile 1 of SUA level were 1.55 (95% CI: 0.95-2.63), 1.62 (95% CI: 0.98-2.67), 1.61 (95% CI: 1.01-2.58), and 1.78 (95% CI: 1.11-2.85) (p for trend = 0.030). The association between SUA level and risk for hypertension and IFG or Type II diabetes was stronger among men with a body mass index (BMI) <24.2 kg/m2 than among men with a BMI > or = 24.2 kg/m2, although the absolute risk was greater in more obese men. These results indicate that SUA level is closely associated with an increased risk for hypertension and IFG or Type II diabetes.
我们在2310名年龄在35至59岁之间、研究开始时没有高血压、空腹血糖受损（IFG）、II型（非胰岛素依赖型）糖尿病或心血管疾病病史的日本男性上班族中进行了为期6年的随访，以研究血清尿酸（SUA）与高血压（血压≥140/90 mmHg和/或接受高血压治疗）以及空腹血糖受损（IFG）（空腹血糖水平为6.1 - 6.9 mmol/l）或II型糖尿病（空腹血糖水平≥7.0 mmol/l和/或接受糖尿病治疗）发生之间的关联。在对高血压和糖尿病的潜在预测因素进行控制后，与SUA水平五分位数第1组相比，第2组患高血压的相对风险为1.27 [95%置信区间（CI）：1.00 - 1.62]，第3组为1.34（95% CI：1.08 - 1.74），第4组为1.48（95% CI：1.18 - 1.89），第5组为1.58（95% CI：1.26 - 1.99）（趋势p值<0.001）。与SUA水平五分位数第1组相比，IFG或II型糖尿病的多变量调整后相对风险分别为1.55（95% CI：0.95 - 2.63）、1.62（95% CI：0.98 - 2.67）、1.61（95% CI：1.01 - 2.58）和1.78（95% CI：1.11 - 2.85）（趋势p值 = 0.030）。SUA水平与高血压以及IFG或II型糖尿病风险之间的关联在体重指数（BMI）<24.2 kg/m²的男性中比在BMI≥24.2 kg/m²的男性中更强，尽管在更肥胖的男性中绝对风险更高。这些结果表明，SUA水平与高血压以及IFG或II型糖尿病风险增加密切相关。
