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Equivalence of hyperfractionated and continuous brachytherapy in a rat tumor model and remarkable effectiveness when preceded by external irradiation.大鼠肿瘤模型中高分割近距离放疗与连续近距离放疗的等效性以及外照射先行时的显著疗效。
Int J Radiat Oncol Biol Phys. 2001 Apr 1;49(5):1351-60. doi: 10.1016/s0360-3016(00)01551-0.

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Accelerated partial breast irradiation using external beam radiotherapy-A feasibility study based on dosimetric analysis.基于剂量学分析的外照射加速部分乳腺照射——一项可行性研究
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本文引用的文献

1
Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011.亚型策略——应对乳腺癌的多样性：2011 年圣加仑国际乳腺癌专家共识会议关于早期乳腺癌初始治疗的要点。
Ann Oncol. 2011 Aug;22(8):1736-47. doi: 10.1093/annonc/mdr304. Epub 2011 Jun 27.
2
Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons.保乳手术术中放疗：1822 例电子治疗病例研究。
Breast Cancer Res Treat. 2010 Nov;124(1):141-51. doi: 10.1007/s10549-010-1115-5. Epub 2010 Aug 15.
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Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial.针对乳腺癌的术中放疗与全乳放疗（TARGIT-A 试验）：一项国际性、前瞻性、随机、非劣效性 3 期试验。
Lancet. 2010 Jul 10;376(9735):91-102. doi: 10.1016/S0140-6736(10)60837-9.
4
Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009).保乳手术后加速部分乳腺照射（APBI）的患者选择：基于临床证据的欧洲癌症治疗研究组织-欧洲放射肿瘤学会（GEC-ESTRO）乳腺癌工作组的建议（2009 年）。
Radiother Oncol. 2010 Mar;94(3):264-73. doi: 10.1016/j.radonc.2010.01.014. Epub 2010 Feb 22.
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Accelerated partial-breast irradiation using high-dose-rate interstitial brachytherapy: 12-year update of a prospective clinical study.应用高剂量率间质近距离放疗行加速部分乳房照射：一项前瞻性临床研究的 12 年更新。
Radiother Oncol. 2010 Mar;94(3):274-9. doi: 10.1016/j.radonc.2010.01.019. Epub 2010 Feb 22.
6
Integrated breast conservation and intraoperative radiation therapy.乳房保留术与术中放疗相结合。
Breast. 2009 Oct;18 Suppl 3:S98-102. doi: 10.1016/S0960-9776(09)70283-8.
7
Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO).美国放射肿瘤学会（ASTRO）关于加速部分乳腺照射的共识声明。
Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):987-1001. doi: 10.1016/j.ijrobp.2009.02.031.
8
Accelerated partial breast irradiation: caution and concern from an ASTRO task force.加速部分乳腺照射：美国放射肿瘤学会特别工作组的谨慎与担忧
Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):981-4. doi: 10.1016/j.ijrobp.2009.03.046.
9
Counterpoint: Conformal external beam for accelerated partial breast irradiation.反驳观点：用于加速部分乳腺照射的适形外照射束
Brachytherapy. 2009 Apr-Jun;8(2):184-188. doi: 10.1016/j.brachy.2009.02.002.
10
Point: Brachytherapy for accelerated partial breast irradiation.观点：近距离放射疗法用于加速部分乳腺照射。
Brachytherapy. 2009 Apr-Jun;8(2):181-183. doi: 10.1016/j.brachy.2009.02.003.

早期乳腺癌的部分乳腺照射技术

Partial breast irradiation techniques in early breast cancer.

作者信息

Kacprowska Agata, Jassem Jacek

机构信息

Department of Oncology and Radiotherapy, Medical University of Gdansk, Debinki 7, 80-952 Gdansk, Poland.

出版信息

Rep Pract Oncol Radiother. 2011 Oct 14;16(6):213-20. doi: 10.1016/j.rpor.2011.08.003.

DOI:10.1016/j.rpor.2011.08.003
PMID:24376983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3863308/
Abstract

Whole breast irradiation represents an integral part of combined breast-conserving treatment of early breast cancer. A new concept includes replacing traditionally fractionated whole breast postoperative radiotherapy by accelerated partial breast irradiation. The latter involves a variety of techniques and may be applied intraoperatively or shortly after the surgery. The intraoperative techniques include photon or electron external beam irradiation and interstitial high dose rate (HDR) brachytherapy, whereas the postoperative techniques comprise interstitial brachytherapy, be it HDR, pulse dose rate (PDR) or low dose rate (LDR), intracavitary brachytherapy and external beam radiotherapy using electrons, photons or protons. This article presents accelerated partial breast irradiation techniques, ongoing phase III trials evaluating their value and recommendations for clinical practice.

摘要

全乳照射是早期乳腺癌保乳综合治疗的一个重要组成部分。一个新的概念是用加速部分乳腺照射取代传统的术后全乳分割放疗。后者涉及多种技术，可在术中或术后不久应用。术中技术包括光子或电子外照射束放疗和组织间高剂量率（HDR）近距离放疗，而术后技术包括组织间近距离放疗，无论是HDR、脉冲剂量率（PDR）还是低剂量率（LDR），腔内近距离放疗以及使用电子、光子或质子的外照射束放疗。本文介绍了加速部分乳腺照射技术、评估其价值的正在进行的III期试验以及对临床实践的建议。