Dmitriev A D, Tennov A V, Tsutsul'kovskaia M Ia, Beliaev B S, Kizim E A
Vopr Med Khim. 1987 Jan-Feb;33(1):88-91.
Radioimmunological procedure enabled to estimate alpha- and gamma-endorphins in human blood plasma without pre-extraction. Basal level of these neuropeptides in peripheric blood plasma of 18 healthy donors constituted: C alpha = 392 +/- 244 pg/ml and C gamma = 20.6 +/- 9.1 pg/ml. Content of these endorphins in blood plasma did not depend on age and sex. Concentration of alpha- and gamma-endorphins were shown to correlate in peripheric blood (r = 0.88); this suggests the overall mechanisms for regulation of their synthesis, secretion and degradation. At the same time, distinct differences in concentrations of alpha- and gamma-endorphins in blood plasma were not found in groups of healthy donors and of patients with endogenous psychoses and pronounced depressive symptoms.
放射免疫程序能够在不进行预提取的情况下估计人血浆中的α-和γ-内啡肽。18名健康献血者外周血浆中这些神经肽的基础水平为：Cα = 392±244 pg/ml，Cγ = 20.6±9.1 pg/ml。血浆中这些内啡肽的含量不取决于年龄和性别。α-和γ-内啡肽的浓度在外周血中显示出相关性（r = 0.88）；这表明它们的合成、分泌和降解存在整体调节机制。同时，在健康献血者组以及患有内源性精神病和明显抑郁症状的患者组中，未发现血浆中α-和γ-内啡肽浓度存在明显差异。
