Burov Iu V, Treskov V G, Iukhananov R Iu, Kovalenko A K
Biull Eksp Biol Med. 1984 Nov;98(11):578-9.
Radioimmunoassay was used to measure the blood content of beta-endorphines in patients with chronic alcoholism. The concentration of endogenous ethanol in these patients was determined by gas chromatography. The blood concentration of beta-endorphines was found to be high in patients who showed atypical affective disorders off the period of abstinence. It is assumed that peripheral beta-endorphine is not linked with the development of the narcomanic syndrome proper but mirrors the pathogenetic mechanisms of psychopathological disorders. The levels of endogenous ethanol vary in alcoholics and healthy subjects within the same ranges. However, the percentage distribution indicates that in patients, they are shifted toward lower concentrations, which is likely to be conditioned by the induction of enzymatic systems that metabolize ethanol.
采用放射免疫分析法测定慢性酒精中毒患者血液中β-内啡肽的含量。通过气相色谱法测定这些患者体内内源性乙醇的浓度。结果发现，在戒酒期出现非典型情感障碍的患者中，β-内啡肽的血液浓度较高。据推测，外周β-内啡肽与成瘾综合征本身的发展并无关联，而是反映了精神病理障碍的发病机制。内源性乙醇水平在酗酒者和健康受试者中的变化范围相同。然而，百分比分布表明，在患者中，其水平向较低浓度偏移，这可能是由乙醇代谢酶系统的诱导所致。
